In the last years, miRNAs have been associated with molecular pathways of cancer and other diseases. The change of expression level of miRNA has an inhibitory role in tumorigenesis. Nevertheless, the poor bioavailability of miRNA due to the rapid enzymatic degradation is a critical handicap in cancer therapy. In this study, we designed dextran-coated iron oxide-based nanoparticle for the delivery of miR-29a to breast cancer cells and analyzed its therapeutic efficacy . Results indicated that the presence of dextran-coated magnetic nanoparticles, loaded with miR29a, enhanced the selective delivery of miR-29a. Further, miR-29a complex nanoparticles caused down-regulation of anti-apoptotic genes. These results pave the way for further investigations into the possible use of miR-29a complex magnetic nanoparticles for breast cancer therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10837450.2019.1623252 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
MicroRNAs and long non-coding RNAs In T-cell lymphoma: Mechanisms, pathway, therapeutic opportunities.
Pathol Res Pract
December 2024
Department of Clinical Laboratory Science, College of Applied Medical Sciences, Al-Quwayiyah, Shaqra University, Riyadh, Saudi Arabia. Electronic address:
T-cell lymphomas represent non-Hodgkin lymphomas distinguished by the uncontrolled proliferation of malignant T lymphocytes. Classifying these neoplasms and the ongoing investigation of their underlying biological mechanisms remains challenging. Significant subtypes encompass peripheral T-cell lymphomas, anaplastic large-cell lymphomas, cutaneous T-cell lymphomas, and adult T-cell leukemia/lymphoma.
View Article and Find Full Text PDFPromotion of angiogenesis and suppression of inflammatory response in skin wound healing using exosome-loaded collagen sponge.
Front Immunol
December 2024
Engineering Research Center in Biomaterials, Sichuan University, Chengdu, China.
Effectively promoting skin wound healing remains a significant challenge in the medical field. Although stem cell-derived exosomes show potential in tissue regeneration, their local delivery and sustained release face challenges. To address these issues, we developed a collagen sponge based on type I and recombinant humanized type III collagen.
View Article and Find Full Text PDFHuman Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Loaded Mir-29-3p Targets AhR to Improve Juvenile Idiopathic Arthritis via Inhibiting the Expression of IL-22 in CD4 T Cell.
Stem Cell Rev Rep
December 2024
Pediatric Immunology and Rheumatology Department, School of Medicine, Chief Physician, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, No.1617, Riyue Avenue, Qingyang District, Chengdu, Sichuan, China.
Article Synopsis
- Juvenile idiopathic arthritis (JIA) is a common chronic inflammatory disease in children, and this study explores how human umbilical cord mesenchymal stem cell-derived exosomes (HUCMSCs-Exos) influence JIA by delivering miR-29-3p to inhibit IL-22 expression in T cells.
- In experiments with a collagen-induced arthritis mouse model and JIA patient T cells, results showed that HUCMSCs-Exos significantly reduced IL-22 levels while increasing miR-29-3p levels, reversing the expression of related genes in T cells.
- Ultimately, the study concludes that HUCMSCs-Exos targeting AhR through miR-29-3p may offer a
HIF-2α-dependent induction of miR-29a restrains T1 activity during T cell dependent colitis.
Nat Commun
September 2024
Department of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel diseases. We hypothesize that HIF could be stabilized in CD4 T cells during intestinal inflammation and alter the functional responses of T cells via regulation of microRNAs. Our assays reveal markedly increased T cell-intrinsic hypoxia and stabilization of HIF protein during experimental colitis.
View Article and Find Full Text PDFMiR-29a-laden extracellular vesicles efficiently induced apoptosis through autophagy blockage in HCC cells.
Eur J Pharm Biopharm
October 2024
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 14155-4364, Iran; Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institute, Stockholm, Sweden. Electronic address:
Article Synopsis
- Even though there have been improvements in treating liver cancer, many patients still don’t do well because their cancer becomes resistant to treatment.
- A tiny molecule called miR-29a is usually low in these cancer patients, and it helps prevent cancer cells from escaping death, which could make treatments better.
- In this study, researchers used special tiny bubbles called extracellular vesicles to deliver miR-29a to cancer cells, and it worked to make the cancer cells die and stop them from growing.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!