Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.rehab.2019.05.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Detection of presymptomatic individuals or those with subtle cognitive changes in midlife may prevent or slow the course of Alzheimer's Disease by identifying candidates for disease-modifying treatments. Utilizing newer delivery approaches involving digital measures shows promise for cognitive phenotyping, early detection, ease of administration, and scoring, particularly in low-resource settings. However, the feasibility of these approaches, along with their association with demographics and their effectiveness in detecting fine-grained aspects of cognitive performance in low-resource settings, remains unclear.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: The burden of Alzheimer's disease and related dementias is growing fast in Africa. The Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the Alzheimer's Disease Sequencing Project (READD-ADSP) has commenced recruitment of 5000 African participants (AD and cognitively unimpaired individuals) to generate genomic and biomarker data to better characterize AD genetic architecture in Africa. Participating countries, part of the African Dementia Consortium (AfDC) include Nigeria, Ghana, Benin, Cameroon, Uganda, Kenya, Ethiopia, Tanzania, and Mozambique.
View Article and Find Full Text PDFBackground: During normal aging, it has been observed that brain regional volume and thickness can be altered due to atrophy. While both 3 Tesla (3T) and 7 Tesla (7T) MRI are used to study such changes, it is unknown how individual brain morphology is characterized differently when 7T MRI allows for higher-resolution and higher tissue contrast images. In this study, we employ a large cohort of healthy subjects that have undergone both 3T and 7T MRI scans to investigate how 7T MRI improves correlation strength between brain morphometrics and aging.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Background: Impaired functional status is a central diagnostic feature of Alzheimer's disease and related dementias (ADRD). Informant reporting is often relied upon, given concerns surrounding the ability of persons with ADRD to validly self-report symptoms. We sought to investigate how cognitive impairment severity impacts psychometric properties of the Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS-PF) scale.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Although associated with early changes in Aβ and tau formations, microtubule (MT) destabilization has not yet been systematically evaluated as an early biomarker of neurodegeneration and a tool to quantify it in real-time could provide information on these early changes in AD cascade. While current Aβ and tau PET approaches can characterize disease lesions, they fall short in capturing earlier molecular events. Our team development the first brain-penetrant MT PET ligand, [C]MPC-6827.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!