Background: Growing body of evidence has opened new opportunities to enhance treatment outcomes during early-phase psychosis (EPP). The objective of this study was to evaluate the effect of the Centre for integrative psychiatry (CIP) multimodal Early Intervention Services (EIS) on time to relapse in the patients with early-phase psychosis (EPP) during 12 and 24 month period.
Subjects And Methods: We performed a retrospective cohort study on the sample of 454 EPP patients (duration of the diagnosed disorder ≤5 years) admitted to Psychiatric Hospital "Sveti Ivan", Zagreb Croatia, from January 2, 2015, to December 5, 2018, for the acute treatment of EPP. The end of follow up was March 5, 2019. The primary outcome was the time to rehospitalization because of relapse during the 12 months from the hospital discharge. Independent variable was the EIS.
Results: We analyzed 454 EPP patients, 260 in EIS group and 194 in no EIS group. After the adjustment for twenty possible confounding factors using the Cox proportional hazard regression, patients who received EIS had significantly and clinically relevantly lower hazard for rehospitalization because of relapse during the first 12 months (HR=0.39; CI 0.21-0.61; p<0.001), and during the first 24 months from the hospital discharge (HR=0.56; CI 0.39-0.80; p=0.003; sequential Holm-Bonferroni corrected p=0.004).
Conclusions: Our study indicated efficacy of the CIP multimodal EIS in patients with EPP demonstrated through the time to the hospital readmission because of relapse during the 12 and 24 months from the hospital discharge. These results strongly support the need for implementation of multimodal EIS in all patients with EPP.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Criminal Offending and Incarceration in United States Adults With Early Phase Psychosis and Comorbid Substance Use Disorder.
Early Interv Psychiatry
February 2025
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Aim: Studies have shown that people experiencing early phase psychosis (EPP) are at increased risk for criminal conviction and incarceration. However, there is limited data looking at overall legal burden. To address these gaps in the literature, the goal of this study was to categorise criminal charges and convictions using the United States Federal Bureau of Investigation (FBI) uniform crime reporting (UCR) program, assess frequency of incarcerations, and describe the frequency of substance use disorder (SUD) diagnoses and its relationship to criminal offending and incarceration in a well categorised EPP population.
View Article and Find Full Text PDFRetina in Clinical High-Risk and First-Episode Psychosis.
Schizophr Bull
November 2024
Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey.
Background And Hypothesis: Abnormalities in the retina are observed in psychotic disorders, especially in schizophrenia.
Study Design: Using spectral-domain optical coherence tomography, we investigated structural retinal changes in relatively metabolic risk-free youth with clinical high-risk (CHR, n = 34) and first-episode psychosis (FEP, n = 30) compared with healthy controls (HCs, n = 28).
Study Results: Total retinal macular thickness/volume of the right eye increased in FEP (effect sizes, Cohen's d = 0.
The COMPASS scale for the assessment of individuals with first episode psychotic disorders.
Schizophr Res
December 2024
The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Departments of Psychiatry and of Molecular Medicine, Hempstead, NY, USA; The Feinstein Institutes for Medical Research, Institute of Behavioral Science, Manhasset, NY, USA; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health System, Glen Oaks, NY, USA. Electronic address:
Background: Psychosis symptom assessment instruments are rarely used in US mental health community clinical practice despite the advantages of measurement-based care. Barriers include the length of typical scales and that data for scale evaluation often come from researcher and not clinician raters.
Study Design: The 12-item COMPASS symptom assessment was designed for the RAISE-ETP study of early phase psychosis.
Outcomes of an adapted prolonged exposure psychotherapy for people with early phase psychosis, substance misuse, and a history of adversity: the PE + trial.
BMC Psychiatry
October 2024
Department of Psychology & Neuroscience, Dalhousie University, Halifax, NS, Canada.
Article Synopsis
- Several trials have shown that adversity-focused treatments can reduce symptoms of PTSD and psychosis, but there is limited research on their effects on substance use, especially in early phase psychosis populations.
- This study tested an adapted prolonged exposure therapy (PE+) on 19 adults with psychotic disorders and substance misuse, assessing multiple outcomes before and after treatment.
- Results indicated significant improvements in some adversity-related areas and participant satisfaction, but there was no overall improvement in psychotic symptoms and substance misuse actually increased for some individuals.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!