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Somatic and germline sequencing in genitourinary oncology: genetics for the clinician. | LitMetric

Somatic and germline sequencing in genitourinary oncology: genetics for the clinician.

Curr Opin Urol

Division of Hematology and Medical Oncology, Englander Institute for Precision Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA.

Published: July 2019

AI Article Synopsis

Article Abstract

Purpose Of Review: Next-generation sequencing is becoming more accessible. This review focuses on the clinical application of somatic and germline sequencing to genitourinary oncology.

Recent Findings: Germline variants have been increasingly recognized as contributing to the development of genitourinary malignancies, particularly in patients with advanced disease. A variety of commercial and institutional technologies are in use to detect variants, with newer tools focused on integrating these results into the clinical workflow.

Summary: DNA sequencing is becoming a valuable tool in caring for patients with genitourinary malignancies. Performing both somatic and germline sequencing will likely become standard practice. Interpretation and clinical application of these results can be challenging and often requires multidisciplinary expertise.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467627PMC
http://dx.doi.org/10.1097/MOU.0000000000000643DOI Listing

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