Mixture item response theory (MixIRT) models can sometimes be used to model the heterogeneity among the individuals from different subpopulations, but these models do not account for the multilevel structure that is common in educational and psychological data. Multilevel extensions of the MixIRT models have been proposed to address this shortcoming. Successful applications of multilevel MixIRT models depend in part on detection of the best fitting model. In this study, performance of information indices, Akaike information criterion (AIC), Bayesian information criterion (BIC), consistent Akaike information criterion (CAIC), and sample-size adjusted Bayesian information criterion (SABIC), were compared for use in model selection with a two-level mixture Rasch model in the context of a real data example and a simulation study. Level 1 consisted of students and Level 2 consisted of schools. The performances of the model selection criteria under different sample sizes were investigated in a simulation study. Total sample size (number of students) and Level 2 sample size (number of schools) were studied for calculation of information criterion indices to examine the performance of these fit indices. Simulation study results indicated that CAIC and BIC performed better than the other indices at detection of the true (i.e., generating) model. Furthermore, information indices based on total sample size yielded more accurate detections than indices at Level 2.
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http://dx.doi.org/10.1177/0146621618779990 | DOI Listing |
Mol Biotechnol
December 2024
Unit of Scientific Research, Applied College, Qassim University, Buraydah, 52571, Saudi Arabia.
The Zika virus (ZIKV), an arbovirus within the Flavivirus genus, is associated with severe neurological complications, including Guillain-Barré syndrome in affected individuals and microcephaly in infants born to infected mothers. With no approved vaccines or antiviral treatments available, there is an urgent need for effective therapeutic options. This study aimed to identify new natural compounds with inhibitory potential against the NS2B-NS3 protease (PDB ID: 5LC0), an essential enzyme in viral replication.
View Article and Find Full Text PDFBehav Res Methods
December 2024
ETSI de Telecomunicación, Universidad Politécnica de Madrid, Avenida Complutense, 30, 28040, Madrid, Spain.
This study investigates the potential of large language models (LLMs) to estimate the familiarity of words and multi-word expressions (MWEs). We validated LLM estimates for isolated words using existing human familiarity ratings and found strong correlations. LLM familiarity estimates performed even better in predicting lexical decision and naming performance in megastudies than the best available word frequency measures.
View Article and Find Full Text PDFSci Rep
December 2024
IRCCS SYNLAB SDN, Naples, 80143, Italy.
LAG3 plays a regulatory role in immunity and emerged as an inhibitory immune checkpoint molecule comparable to PD-L1 and CTLA-4 and a potential target for enhancing anti-cancer immune responses. We generated 3D cancer cultures as a model to identify novel molecular biomarkers for the selection of patients suitable for α-LAG3 treatment and simultaneously the possibility to perform an early diagnosis due to its higher presence in breast cancer, also to achieve a theragnostic approach. Our data confirm the extreme dysregulation of LAG3 in breast cancer with significantly higher expression in tumor tissue specimens, compared to non-cancerous tissue controls.
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December 2024
School of Management, Hefei University of Technology, Hefei, People's Republic of China.
Medical devices (MDs) play a critical role in healthcare delivery while also bringing potential medical risks and unintended harms to patients. Although government regulation is well recognized as a critical and essential function for ensuring the safety of MDs in many countries, the supplementary role that hospitals play is often neglected. This paper constructs a tripartite evolutionary game model involving the government, hospitals, and MDs enterprises to explore their strategic behaviors of MDs regulation in healthcare delivery.
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December 2024
Department of Pharmacy Services, Vocational School of Health Services, Osmaniye Korkut Ata University, Osmaniye, Turkey.
In this work, artificial neural network coupled with multi-objective genetic algorithm (ANN-NSGA-II) has been used to develop a model and optimize the conditions for the extracting of the Mentha longifolia (L.) L. plant.
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