Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41436-019-0556-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The proton RBE and the distal edge effect for acute and late normal tissue damage in vivo.
Radiother Oncol
December 2024
Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark; Danish Center for Particle Therapy, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University Hospital, Denmark.
Background And Purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used toreach an isoeffective biological response between photon and proton doses. However, the RBE varies with biological endpoints and linear energy transfer (LET), two key parameters in radiotherapy.
View Article and Find Full Text PDFLight-exercise-induced dopaminergic and noradrenergic stimulation in the dorsal hippocampus: Using a rat physiological exercise model.
FASEB J
December 2024
Laboratory of Exercise Biochemistry and Neuroendocrinology, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
Exercise activates the dorsal hippocampus that triggers synaptic and cellar plasticity and ultimately promotes memory formation. For decades, these benefits have been explored using demanding and stress-response-inducing exercise at moderate-to-vigorous intensities. In contrast, our translational research with animals and humans has focused on light-intensity exercise (light exercise) below the lactate threshold (LT), which almost anyone can safely perform with minimal stress.
View Article and Find Full Text PDFThe antitumor activity of TGFβ-specific T cells is dependent on IL-6 signaling.
Cell Mol Immunol
January 2025
National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Although interleukin (IL)-6 is considered immunosuppressive and tumor-promoting, emerging evidence suggests that it may support antitumor immunity. While combining immune checkpoint inhibitors (ICIs) and radiotherapy in patients with pancreatic cancer (PC) has yielded promising clinical results, the addition of an anti-IL-6 receptor (IL-6R) antibody has failed to elicit clinical benefits. Notably, a robust TGFβ-specific immune response at baseline in PC patients treated solely with ICIs and radiotherapy correlated with improved survival.
View Article and Find Full Text PDFDetection of human IgG antibodies against using a recombinant MG075 antigen.
medRxiv
November 2024
Reproductive Microbiology, Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Article Synopsis
- The text discusses the development of a serological test to identify a sexually transmitted pathogen that affects reproductive health in both genders.
- It highlights the challenges faced due to cross-reactivity with a similar respiratory pathogen, making accurate testing difficult.
- The newly developed immunoblot assay shows promising results with a sensitivity of 87.1% and specificity of 95.2%, which could enhance understanding of the pathogen's impact on reproductive complications.
Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression.
Br J Psychiatry
December 2024
Neurobiology Research Unit, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Background: Using [F]altanserin, a serotonin 2A receptor (5-HTR) antagonist Positron Emission Tomography (PET) tracer, a positive association between cortical 5-HTR binding and the inward-directed facets of neuroticism has been demonstrated in healthy individuals. Psilocybin, a 5-HTR agonist, shows promise for the treatment of depression, reducing neuroticism and mood symptoms potentially via hypothalamic-pituitary-adrenal (HPA) modulation. 5-HTR and neuroticism are both modulated by HPA axis function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!