Purpose: This study compared loading, elution, and stability of drug-eluting embolic beads (DEBs) loaded with idarubicin.
Materials And Methods: DC Bead (100-300 μm), HepaSphere (30-60 μm), LifePearl (200 μm), and Tandem (100 μm) DEBs were loaded with 5 mg/mL idarubicin. Loading, elution, diameter changes, loading stability over 2 weeks in storage, and time in suspension were determined for each of the DEBs.
Results: Loading of more than 99% of idarubicin was achieved within 15 minutes for LifePearl, DC Bead, and Tandem beads. LifePearl, DC Bead, HepaSphere, and Tandem beads eluted 75% of the total idarubicin released in 13, 24, 42, and 91 minutes, respectively. In vitro elution was completed in 2 hours with 73% ± 3%, 74% ± 3%, 65% ± 6%, and 7% ± 0% of the loaded idarubicin eluted for LifePearl, DC Bead, HepaSphere, and Tandem, respectively. Statistically significant differences were observed at every time point between at least 2 of the products. Overall, in vitro idarubicin elution was rapid and nearly complete for LifePearl, DC Bead, and HepaSphere beads but was minimal and slow from Tandem beads. The average diameter of DEBs after loading was reduced by 5% for LifePearl, whereas it was increased by 9% and 1% for DC Bead and Tandem, respectively. After loading, time in suspension was 11 ± 4 and 10 ± 2 minutes for LifePearl and HepaSphere, respectively, whereas DC Bead and Tandem beads were held in suspension for greater than 20 minutes.
Conclusions: Although all 4 DEBs loaded idarubicin within 15 minutes with minimal changes in diameter, the elution amounts, rates of release, and time in suspension varied.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jvir.2018.12.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An In Vitro Evaluation of Four Types of Drug-Eluting Embolics Loaded with Idarubicin.
J Vasc Interv Radiol
August 2019
MicroVention, Inc., Aliso Viejo, California.
Purpose: This study compared loading, elution, and stability of drug-eluting embolic beads (DEBs) loaded with idarubicin.
Materials And Methods: DC Bead (100-300 μm), HepaSphere (30-60 μm), LifePearl (200 μm), and Tandem (100 μm) DEBs were loaded with 5 mg/mL idarubicin. Loading, elution, diameter changes, loading stability over 2 weeks in storage, and time in suspension were determined for each of the DEBs.
Characterizing Drug-Polymer Bead Interactions Using Isothermal Titration Calorimetry.
J Pharm Sci
May 2019
School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK. Electronic address:
Isothermal titration calorimetry was used to investigate thermodynamic and kinetic binding interactions between 4 clinically relevant drugs: doxorubicin (Dox), irinotecan (Iri), mitoxantrone (Mitox), and topotecan (Topo) and a range of commercially available embolization microspheres. Five drug-eluting beads were chosen to consider the effect of bead size (ranging from 70-150 μm to 500-700 μm) and bead type (sulfonate-modified polyvinylalcohol hydrogel, known commercially as DC BeadM1™, and a sulfonate-modified polyethylene glycol hydrogel bead, known commercially as LifePearl™). The molar ratio of drug to SO was found to be 0.
View Article and Find Full Text PDFAn in-vitro evaluation of three types of drug-eluting microspheres loaded with irinotecan.
Anticancer Drugs
October 2016
aClinic of Radiology, Minimally Invasive Therapies and Nuclear Medicine, SLK-Kliniken GmbH, Academic Hospital, Ruprecht-Karls-University Heidelberg bClinic of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany cMicroVention Inc., Tustin, California, USA.
To compare the mechanical and chemical properties of three commercially available microspheres loaded with irinotecan. LifePearl (200 µm), DC Bead (100-300 µm), and Tandem (100 µm) microspheres were loaded with irinotecan. For loading, elution, and stability determinations, irinotecan concentrations were quantified using validated high-performance liquid chromatography methods.
View Article and Find Full Text PDFAn In Vitro Evaluation of Four Types of Drug-Eluting Microspheres Loaded with Doxorubicin.
J Vasc Interv Radiol
September 2016
MicroVention, Tustin, California.
Purpose: To compare in vitro properties of 4 drug-eluting embolic agents loaded with doxorubicin.
Materials And Methods: DC Bead (100-300 µm), LifePearl (200 µm), HepaSphere (30-60 µm), and Tandem (100 µm) microspheres were loaded with 40 mg/20 mL of doxorubicin per milliliter of microspheres. Loading, elution, diameter changes after loading, changes in the amount of doxorubicin loaded over 2 weeks in storage, and time in suspension were evaluated.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!