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AI-Driven insights in pancreatic cancer imaging: from pre-diagnostic detection to prognostication.
Abdom Radiol (NY)
December 2024
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States, largely due to its poor five-year survival rate and frequent late-stage diagnosis. A significant barrier to early detection even in high-risk cohorts is that the pancreas often appears morphologically normal during the pre-diagnostic phase. Yet, the disease can progress rapidly from subclinical stages to widespread metastasis, undermining the effectiveness of screening.
View Article and Find Full Text PDF[Genetic analysis of a Chinese pedigree affected with Branchio-oculo-facial syndrome and a literature review].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
September 2024
Genetic and Prenatal Diagnosis Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Article Synopsis
- The study investigates the genetic causes of Branchio-oculo-facial syndrome (BOFS) in a Chinese family and summarizes the prenatal characteristics of BOFS patients.
- The researchers conducted trio-whole exome sequencing on the fetus and its parents, finding a likely pathogenic variant in the TFAP2A gene common among affected family members.
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Metabolic signatures derived from whole-brain MR-spectroscopy identify early tumor progression in high-grade gliomas using machine learning.
J Neurooncol
December 2024
Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
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Development and validation of a predictive model for end-stage renal disease in systemic lupus erythematosus patients.
Rheumatol Int
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Department of Pharmacy, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Systemic lupus erythematosus (SLE) affects many populations. This study aims to develop a predictive model and create a nomogram for assessing the risk of end-stage renal disease (ESRD) in patients diagnosed with SLE. Data from electronic health records of SLE patients treated at the Affiliated Hospital of North Sichuan Medical College between 2013 and 2023 were collected.
View Article and Find Full Text PDFFirst-Generation Radiolabeled Cyclic Peptides for Molecular Imaging of Platelet-Derived Growth Factor Receptor α.
Mol Pharm
September 2024
Department of Surgery, University of Alberta, Edmonton, Canada T6G 2B7.
Occult nodal spread and metastatic disease require longstanding imaging and biochemical assessments for thyroid cancer, a disease that has a propensity for diffuse, small-volume disease. We have developed a Cu-labeled platelet-derived growth factor receptor α (PDGFRA) antibody for immuno-PET of PDGFRA in metastatic papillary thyroid cancer (PTC). The present work describes the discovery of small cyclic PDGFRA-targeting peptides, their binding features, and radiolabeling with positron emitter gallium-68 (Ga) for characterization in thyroid cancer models.
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