Correlations of the frequency dependence of the ultrasonic backscatter coefficient with the bone volume fraction and the trabecular thickness in bovine trabecular bone: Application of the binary mixture model.

The ultrasonic backscatter coefficient and the exponent n (frequency dependence of the backscatter coefficient) were measured in 24 bovine femoral trabecular bone samples. The binary mixture model for ultrasonic scattering from trabecular bone was applied to predict the variations of the ultrasound parameters with the bone volume fraction (BV/TV) and the trabecular thickness (Tb.Th) in trabecular bone. The backscatter coefficient exhibited significant, positive correlations with the BV/TV (R = 0.82) and the Tb.Th (R = 0.79). In contrast, the exponent n was found to be significantly, negatively correlated with the BV/TV (R = -0.77) and the Tb.Th, (R = -0.71).