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Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology.
Front Cell Neurosci
February 2022
Neuroscience Interdepartmental Program, Iowa State University, Ames, IA, United States.
Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate novel therapeutics for acute and chronic effects. However, civilians are not premedicated with pyridostigmine/oxime.
View Article and Find Full Text PDFQT prolongation in non-telemetered hospitalized elderly patients.
J Electrocardiol
June 2021
Beaumont Hospital, Beaumont Road, Dublin 8, Ireland.
Sensitivity of common marmosets to detect drug-induced QT interval prolongation: moxifloxacin case study.
J Pharmacol Toxicol Methods
December 2010
Fuji Gotemba Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513, Japan.
Introduction: Moxifloxacin is the most widely used positive reference agent in clinical cardiac repolarization studies, but it has not been characterized in common marmosets which are uniquely suited to studies in early-stage development due to their small size and minimal test article requirements. The purpose of this study was to evaluate the sensitivity of the common marmoset to detect moxifloxacin-associated QT interval prolongation.
Methods: Eight telemetered common marmosets were monitored for 24 h following oral administration of moxifloxacin by gavage at 0, 10, 30, and 100 mg/kg using a Latin square design.
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