Keys to unlock androgen receptor translocation.

J Biol Chem

From Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 1L3, Canada

Published: May 2019

The androgen receptor (AR) is tightly linked to prostate cancer, but the mechanisms by which AR transactivation is dysregulated during cancer progression are not fully explored. Dagar examined AR translocation to the nucleus to identify a link between heat shock protein 90 (HSP90) and protein kinase A (PKA). Their findings provide a potential mechanism of the initiation of AR transactivation and potential targets for developing and refining treatments for prostate cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552410PMC
http://dx.doi.org/10.1074/jbc.H119.009180DOI Listing

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