We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456340PMC
http://dx.doi.org/10.1093/cid/ciz455DOI Listing

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