Introduction: Ameloblastoma is the most common odontogenic tumour in Nigeria. A definite geographic variation has been observed in the frequency of odontogenic tumors from different parts of the world. However, there is no study on the regional variations in Nigeria. Hence, this study was designed to document the ethnic and geographical distribution of jaw ameloblastoma in Nigeria.
Methods: Archival data on ameloblastoma from 10 health facilities were obtained. Global Moran's I detected geographic clustering in its distribution while Local Getis Ord indicated the location of ameloblastoma clusters. Chi-square tested associations between variables at 0.05 level of significance.
Results: A total of 1,246 ameloblastoma cases were recorded in Nigeria. Besides substantial state variations, a South-North gradient was noticed in its distribution. Significant positive spatial autocorrelation was observed in the three major groups while ameloblastoma hotspots were found in the SouthWestern and Northwestern Nigeria. The Igbos had a higher prevalence of ameloblastoma outside their home region than within.
Conclusion: The study hypothesized that the geographical distribution of ameloblastoma in Nigeria is the result of all or one of the following: the country's tropical climate, migration patterns and health seeking behavior. Hopefully, these claims should lead to further enquiry on the underlying causes.
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http://dx.doi.org/10.4314/ahs.v19i1.44 | DOI Listing |
Semin Diagn Pathol
December 2024
Department of Oral Pathology & Microbiology, King George's Medical, University, Lucknow 226003 UP, India. Electronic address:
Ameloblastoma represents a rare and locally aggressive odontogenic neoplasm, notable for its histopathological diversity. Among its subtypes, the desmoplastic and plexiform variants are relatively rare, with the hybrid form, encompassing both architectural patterns, representing an even more exceptional entity. This article delineates the clinical, radiological, and histopathological profile of a 45-year-old male presenting with pain persisting over the past month in the right posterior maxillary region.
View Article and Find Full Text PDFCureus
November 2024
Oral and Maxillofacial Surgery, Burdwan Dental College and Hospital, Burdwan, IND.
Peripheral ameloblastoma is a rare, benign, slow-growing odontogenic neoplasm prevalent in the mandible. It originates from the odontogenic epithelium and its remnants, and its histological characteristics are identical to those of intraosseous ameloblastoma. It is less aggressive and invasive than its intraosseous variety, with a low recurrence rate.
View Article and Find Full Text PDFMod Pathol
December 2024
Liverpool Head and Neck Centre, Molecular and Clinical Cancer Medicine, University of Liverpool, 6 West Derby Street, Liverpool, L6 8TX. Electronic address:
Ameloblastoma (AM) is a benign but locally infiltrative epithelial odontogenic neoplasm of the jawbones that may reach grotesque proportions and be highly recurrent if inadequately removed. The BRAF mutation has been demonstrated as key molecular event in its development, nevertheless, there are many queries about its aetiopathogenesis that are yet to be answered. In this study, we aimed to integrate results from whole-exome sequencing (WES) and RNA-sequencing in AM samples to identify novel candidate genes that may be relevant to its pathogenesis.
View Article and Find Full Text PDFCureus
November 2024
Otolaryngology and Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, JPN.
This report presents a notable approach to treating a locally invasive maxillary ameloblastoma in a 46-year-old woman using an endoscopy-assisted total maxillectomy via a contralateral transmaxillary approach without a subciliary incision. Ameloblastomas, though benign, require radical surgical management due to their aggressive nature and high recurrence rates, especially in the maxilla. Traditional techniques often involve extensive facial incisions, leading to significant scarring and potential complications.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo 145-8515, Japan.
Pulmonary metastasis of ameloblastoma is a rare associated with the histopathologically plexiform types of ameloblastoma. In this report, we present an exceptionally rare case of pulmonary metastatic ameloblastoma without local recurrence, emerging 12 years post-initial resection. A female patient, initially diagnosed with mandibular desmoplastic ameloblastoma, revealed masses in both lung fields of the lung on chest radiography, while chest computed tomography revealed more than 10 nodules in both lungs.
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