AI Article Synopsis

  • - The study investigates how repeated exposure to nickel can cause chronic inflammation and allergic contact dermatitis (ACD) by looking at immune activation in sensitized patients.
  • - It involved 35 patients with nickel contact dermatitis (mostly females) and 20 healthy controls with negative patch tests, analyzing their blood for immune responses using flow cytometry to measure CD69 expression on T cells.
  • - Results showed that ACD patients had significantly higher levels of CD69 expression on CD4 and CD8 T lymphocytes when exposed to nickel compared to controls, highlighting CD69 as a key player in the immune response to nickel.

Article Abstract

Background: Persistent antigenic stimulation due to repeated exposure to nickel may lead to chronic inflammation resulting in allergic contact dermatitis (ACD).

Objectives: This study was performed to assess nickel induced immune activation among patients sensitized against nickel.

Patients And Methods: A total of 35 patients (29 females and 6 males; mean age 36±9 years) with nickel contact dermatitis and 20 patch test negative healthy individuals (14 females and 6 males; mean age 29±7 years) were included in this study. Peripheral blood of patients and controls was incubated with nickel sulfate for 24 hours. Immune activation was assessed by CD69 up-regulation on T lymphocyte sub-sets by flow cytometry.

Results: Base line expression of CD69 on CD8 lymphocytes was higher among patients compared to controls (4.1±1.3%vs2.8±1.1%;p<0.009). There was no difference in proportions of CD±CD69 cells between patients and controls (3.2±0.9%vs2.3±0.8%). Exposure to nickel induced expression of CD69 on a significantly higher proportion of CD4 lymphocytes (22.1±6.2%) of the ACD patients compared to controls (2.8±2.5%;p<0.0001). Similarly nickel induced CD69 expression on a higher proportion of CD8 lymphocytes (18.2±5.3%) from ACD patients compared to the controls (1.9±1.8%;p<0.0006).

Conclusion: CD69 molecule appears to be an important regulator of immune response in nickel contact dermatitis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531931PMC
http://dx.doi.org/10.4314/ahs.v19i1.19DOI Listing

Publication Analysis

Top Keywords

contact dermatitis
12
lymphocyte sub-sets
8
nickel induced
8
immune activation
8
females males
8
males age
8
nickel
6
patients
5
nickel challenge
4
challenge regulates
4

Similar Publications

Allergens in ophthalmic medicaments in New Zealand.

Australas J Dermatol

December 2024

Department of Dermatology, Auckland City Hospital, Te Whatu Ora Health, New Zealand.

Background/objectives: Eyelid allergic contact dermatitis (ACD) attributed to ophthalmic medications is often underreported, which can result in poor outcomes. Patch testing for eyelid ACD requires up-to-date knowledge of potential allergens. The aim of this study was to investigate allergens in ophthalmic medicaments in New Zealand.

View Article and Find Full Text PDF

is a plant widely cultivated for food and medicinal purposes. species have been reported as anti-inflammatory, antibacterial, anxiolytic, and antinephritic agents. This study aimed to evaluate the anti-inflammatory potential of the ethanolic extract (EE) from the aerial parts of and its most promising fraction in models of acute and chronic inflammation, including a psoriasis-like mouse model.

View Article and Find Full Text PDF

[Epicutaneous tests with dental materials before and during COVID-19 pandemic in the Central Hungary region].

Orv Hetil

December 2024

1 Észak-pesti Centrumkórház-Honvédkórház, Dermatoallergológiai Szakambulancia Budapest, Németvölgyi út 21., 1126 Magyarország.

View Article and Find Full Text PDF

Background: Allergic contact dermatitis cannot be reliably differentiated from other forms of spongiotic/eczematous dermatitis by histology alone. Textbooks and recent studies have variably supported the specificity of dermal eosinophils, eosinophilic spongiosis, and Langerhans cell collections, among other features.

Objective: To assess which histopathologic features favor a diagnosis of allergic contact dermatitis.

View Article and Find Full Text PDF

Background: 2-(Thiocyanomethylthio)benzothiazole (TCMTB) is a fungicide product widely used in the leather industry, particularly since the 1990s. However, reports of allergic contact dermatitis triggered by this chemical are scarce.

Objectives: To investigate three cases of dermatitis following contact with leather products, possibly related to TCMTB.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!