Discovery of broflanilide, a novel insecticide.

Broflanilide (), discovered by Mitsui Chemicals Agro, Inc., has a unique chemical structure characterized as a -diamide and exhibits high activity against various pests, including Lepidopteran, Coleopteran, and Thysanopteran pests. Because broflanilide has a novel mode of action, the Insecticide Resistance Action Committee (IRAC) categorized it as a member of a new group: Group 30. The -diamide structure was generated drastic structural modification of a lead compound, flubendiamide (), and the subsequent structural optimization of -diamides on each of its three benzene rings led to the discovery of broflanilide. In the present study, the details of the generation of -diamides from the lead compound and the structural optimization of -diamides are described.