Superior vena cava syndrome (SVCS) is an oncological emergency. It is expected that the incidence of SVCS may rise with the increase in usage of central lines for both oncological and non-oncological reasons. The authors of this article present a case study in which a 56-year-old female patient presented at the emergency department with a three-week history of facial swelling, significant hearing loss, unrelenting cough, hoarseness, and swelling of the arms, chest and upper back. A CT scan demonstrated total occlusion of the superior vena cava, confirming SVCS. In this case report, the authors present a discussion of the causes of SVCS, its clinical presentation in relation to this patient's history, and the intervention provided to this patient.
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Indian J Thorac Cardiovasc Surg
February 2025
Dept of CTVS, NEIGRIHMS, Shillong, India.
Isolated right superior vena cava (RSVC) drainage into the left atrium (LA) is a rare congenital anomaly, presenting diagnostic and management challenges. This study presents two cases of isolated RSVC drainage into the LA alongside a comprehensive literature review to improve understanding and delineate optimal surgical approaches. The study describes two cases of isolated RSVC drainage into the LA and their surgical management.
View Article and Find Full Text PDFJACC Case Rep
January 2025
Division of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Fibrosing mediastinitis is a rare chronic inflammatory condition characterized by excessive fibrotic process in the mediastinum. Although various infectious processes are more common causes, it can also be related to several malignancies. We report a case of a 28-year-old woman with fibrosing mediastinitis related to an aggressive primary gray-zone lymphoma causing complete occlusion of the superior vena cava (SVC) and the innominate veins.
View Article and Find Full Text PDFJACC Case Rep
December 2024
Jesselson Integrated Heart Center, The Eisenberg R&D Authority, Shaare Zedek Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Objective: This study sought to present the endovascular approach of transcatheter aspiration using the FlowTriever (Inari Medical) aspiration system for high surgical risk patients with right-sided infective endocarditis.
Key Steps: General anesthesia and transesophageal echocardiogram guidance; ultrasonography-guided femoral vein access, preclosure sutures, and insertion of a 24-F sheath; insertion of straight 24-F aspiration cannula over a stiff wire, parked in the superior vena cava; introduction of a 20-F curved cannula inside the 24-F cannula to create a telescopic assembly; accurate positioning using the right ventricle inflow/outflow projection in biplane mode; adjustment of the curved cannula radius by sliding the inner cannula in and out inside the mother cannula; manual aspiration of the vegetation; Postaspiration transesophageal echocardiogram assessment.
Potential Pitfalls: Avoid leaflet and annular injury and account for potential embolization.
Intern Emerg Med
January 2025
Department of Clinical and Experimental Medicine, Internal Medicine Unit, University of Catania, University Hospital G.Rodolico, Catania, Italy.
JNCI Cancer Spectr
January 2025
Section on Medical Neuroendocrinology National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892, MD, USA.
Head and neck paragangliomas (HNPGLs) are typically slow-growing, hormonally inactive tumors of parasympathetic paraganglia. Inactivation of prolyl-hydroxylase domain-containing 2 protein causing indirect gain-of-function of hypoxia-inducible factor-2α (HIF-2α), encoded by EPAS1, was recently shown to cause carotid body hyperplasia. We previously described a syndrome with multiple sympathetic paragangliomas caused by direct gain-of-function variants in EPAS1 (Pacak-Zhuang syndrome, PZS) and developed a corresponding mouse model.
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