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Genomic metrics made easy: what to do and where to go in the new era of bacterial taxonomy. | LitMetric

Genomic metrics made easy: what to do and where to go in the new era of bacterial taxonomy.

Crit Rev Microbiol

a Departamento de Genética, Instituto de Biociências , Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil.

Published: March 2019

AI Article Synopsis

  • Traditional methods for classifying bacteria, like DNA-DNA hybridization and 16S rRNA analysis, are being replaced by advanced genomic metrics due to high-throughput DNA sequencing technology.
  • The increasing availability of genome sequences in public databases offers a wealth of data for improving bacterial classification.
  • This review aims to compare various genomic metrics and tools, emphasizing their methodologies, effectiveness, limitations, and user-friendliness to assist with bacterial identification.

Article Abstract

With the advent of high-throughput DNA sequencing technologies, traditional methodologies for taxonomic classification of bacteria as DNA-DNA hybridization and 16S rRNA identity analyses are being challenged by the development of a fast-growing number of genomic metrics. The large amount of portable and digitized genome sequences available in public repositories constitutes an invaluable data for bacterial classification. Consequently, several genomic metrics and tools were developed to aid the interpretation of these massive data. Genomic metrics are based on the assumption that higher genome similarities would reflect closer phylogenetic relationships. Different metrics would vary in their methodology of analysis, resolution power, limitations and easiness of use. The aim of this review is to highlight the differences among available genome-based methods and tools to provide a guide for bacterial identification and classification.

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Source
http://dx.doi.org/10.1080/1040841X.2019.1569587DOI Listing

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