Crotoliganfuran, a new clerodane-type furano-diterpenoid from Pierre ex Hutch.

The phytochemical investigation of the methanol extract of the bark of Pierre ex Hutch yielded a new clerodane-type diterpenoid crotoliganfuran () along with ten other compounds including 12-epicrotocorylifuran (), lupeol (), syringic acid (), aleuritolic acid acetate (), aleuritolic acid (), scopoletin (), geddic acid (), -sitosterol (), vanilic acid () and stigmastane-3,6-dione (). Their structures were established by spectroscopic means. The extract and all the isolates were screened for their inhibitory properties against butyrylcholinesterase and urease enzymes, respectively. The extract and compounds , and displayed the most potent urease inhibitory properties with IC values, 22.2, 26.7 and 28.5 M, respectively. Compound was the most active of all the tested compounds against butyrylcholinesterase enzyme with an IC value of 36.3 M.[Formula: see text].