Two new polyketides, xerucitrinin A () and coniochaetone M (), and one new steroid, 16-methylpregna-17,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (), together with eleven known analogues were isolated from fungus SCSIO 41017 associated with the sponge sp. Their structures and absolute configurations were elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, and compared with literature data. Biological evaluation results revealed that exhibited significant cytotoxic activity against MCF-7 cell line with IC values of 1.3 M. Compound showed moderate activity against all cell lines with IC values of 13.5-18.0 M, and compounds and showed weak activity with MIC values of ranging from 125 g/mL to 250 g/mL respectively.[Formula: see text].
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