Urban source water protection planning requires the characterization of sources of contamination upstream of drinking water intakes. Elevated pathogen concentrations following Combined Sewer Overflows (CSOs) represent a threat to human health. Quantifying peak pathogen concentrations at the intakes of drinking water plants is a challenge due to the variability of CSO occurrences and uncertainties with regards to the fate and transport mechanisms from discharge points to source water supplies. Here, a two-dimensional deterministic hydrodynamic and water quality model is used to study the fluvial contaminant transport and the impacts of the upstream CSO discharges on the downstream concentrations of Escherichia coli in the raw water supply of two drinking water plants, located on a large river. CSO dynamic loading characteristics were considered for a variety of discharges. As a result of limited Cryptosporidium data, a probability distribution of the ratio of E. coli to Cryptosporidium based on historical data was used to estimate microbial risk from simulated CSO-induced E. coli concentrations. During optimal operational performance of the plants, the daily risk target was met (based on the mean concentration during the peak) for 80% to 90% of CSO events. For suboptimal performance of the plants, these values dropped to 40% to 55%. Mean annual microbial risk following CSO discharge events was more dependent on treatment performance rather than the number of CSO occurrences. The effect of CSO-associated short term risk on the mean annual risk is largely dependent on the treatment performance as well as representativeness of the baseline condition at the intakes, demonstrating the need for assessment of treatment efficacy. The results of this study will enable water utilities and managers with a tool to investigate the potential alternatives in reducing the microbial risk associated with CSOs.
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http://dx.doi.org/10.1016/j.scitotenv.2019.05.130 | DOI Listing |
Gastrointestinal (GI) colonization by methicillin-resistant (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune and microbial factors that permit GI colonization remain unknown. Male sex is correlated with enhanced nasal carriage, skin and soft tissue infections, and bacterial sepsis.
View Article and Find Full Text PDFMicrobiome
January 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Background: Antimicrobial resistance poses a significant threat to global health, with its spread intricately linked across human, animal, and environmental sectors. Revealing the antimicrobial resistance gene (ARG) flow among the One Health sectors is essential for better control of antimicrobial resistance.
Results: In this study, we investigated regional ARG transmission among humans, food, and the environment in Dengfeng, Henan Province, China by combining large-scale metagenomic sequencing with culturing of resistant bacterial isolates in 592 samples.
Sci Rep
January 2025
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, China.
Limited research has explored the connection between consuming dietary probiotics in the diet and cancer-related deaths. This study aimed to examine how the intake levels of three different groups of dietary probiotics are associated with the risk of dying from cancer in a representative sample of adults in the United States. Using data from the USDA Food Survey Nutrient Database, researchers categorized foods based on their microbial levels as low (10 CFU/g), medium (10-10 CFU/g), or high (> 10 CFU/g).
View Article and Find Full Text PDFClin Biochem
January 2025
Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address:
Introduction: Healthcare systems face several challenges, with microbial infections being one of the main concerns. Therapeutic drug monitoring (TDM) is a strategy that has been encouraged to optimize antimicrobial regimens, particularly those with significant toxicity and narrow therapeutic indices, such as amikacin (AMK). We aimed to evaluate AMK concentrations of patients in a non-routine TDM setting and compare the performance of immunoassay and chromatography methods for routine clinical use.
View Article and Find Full Text PDFAm J Infect Control
January 2025
Nursing School, Universidade Estadual de Campinas (Unicamp), Faculdade de Enfermagem - Universidade Estadual de Campinas (Unicamp). Rua Tessália Vieira de Camargo, 126 - Cidade Universitária Zeferino Vaz. CEP 13083-887, Campinas, São Paulo, Brazil. Electronic address:
Background: The presence of microorganisms in laryngoscopes emphasizes the risk to patient safety during orotracheal intubations.
Methods: Cross-sectional study was carried out in university hospital in the inpatient, emergency, intensive care and surgical center sectors. Microorganisms were recovered from the blades using a filter membrane and from the handles using swab.
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