AI Article Synopsis
- Even though we have personalized medicine that provides treatments based on individual needs, finding drugs that can work for many types of cancer at once would be a big improvement!
- This article talks about new ideas and treatment options that focus on how cancer cells use energy from mitochondria, which are like the power plants of our cells!
- Some older medications, like antibiotics and diabetes drugs, might help stop the growth of different cancers, especially by targeting a process called oxidative phosphorylation!
Article Abstract
Although we have entered the era of personalized medicine and tailored therapies, drugs that target a large variety of cancers regardless of individual patient differences would be a major advance nonetheless. This review article summarizes current concepts and therapeutic opportunities in the area of targeting aerobic mitochondrial energy metabolism in cancer. Old drugs previously used for diseases other than cancer, such as antibiotics and antidiabetics, have the potential to inhibit the growth of various tumor entities. Many drugs are reported to influence mitochondrial metabolism. However, here we consider only those drugs which predominantly inhibit oxidative phosphorylation.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613924 | PMC |
| http://dx.doi.org/10.1016/j.semcdb.2019.05.025 | DOI Listing |
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