Obsessive compulsive disorder (OCD) is a disabling condition, often associated with early onset and chronic course. Early onset combined to the secretiveness that frequently characterises the condition, as well as patient's beliefs that OC symptoms do not represent a medical condition and that OCD can remit spontaneously, are all factors contributing to delayed diagnosis and first treatment, particularly of pharmacological nature. In this short report, authors performed a review of the most recent literature in the field. The current literature clearly delineates a duration of untreated illness of several years (around 7 years in the majority of the reports), which represented, on average, a portion ranging between the 40 and 70% of the overall duration of untreated illness.
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http://dx.doi.org/10.1080/13651501.2019.1621348 | DOI Listing |
Free Radic Res
December 2024
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Patients with hypoxemia require high-concentration oxygen therapy. However, prolonged exposure to oxygen concentrations 21% higher than physiological concentrations (hyperoxia) may cause oxidative cellular damage. Pulmonary alveolar epithelial cells are major targets for hyperoxia-induced oxidative stress.
View Article and Find Full Text PDFACS Omega
December 2024
School of Physical Science and Technology, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.
Photocatalysts composed of ZnSe nanorods were prepared by using a glancing angle deposition technique facilitated by electron beam evaporation equipment. To enhance the photocatalytic efficiency of ZnSe, a vulcanization process was introduced. The impact of various parameters, including curing temperature, duration, and nanorod length, on the photocatalytic performance was systematically examined.
View Article and Find Full Text PDFDermatol Ther (Heidelb)
December 2024
Inovapotek, Pharmaceutical Research & Development, Porto, Portugal.
Introduction: The human skin acts as a protective barrier against external pathogens and hosts a diverse microbiome consisting of bacteria, fungi, viruses, and archaea. Disruptions to the skin microbiome can impact immune function, leading to inflammatory and autoimmune conditions. The importance of pH for the microbiome is paramount.
View Article and Find Full Text PDFJ Neurol
December 2024
Department of Neurology, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle (Saale), Germany.
Background: People with multiple sclerosis (PwMS) experience various degrees of cognitive impairment (CI). Synaptic dysfunction may contribute to CI in PwMS but cerebrospinal fluid (CSF) synaptic biomarkers are unexplored in MS.
Objective: To assess the role of CSF synaptosomal-associated protein 25 (SNAP-25), β-synuclein, neurogranin and neurofilament light chain protein (NfL) in patients with early relapsing MS with and without CI.
J Drug Target
December 2024
Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Treating burn lesions has always been challenging because any product should be cheap, accessible, and have anti-bacterial commodities and tissue regeneration properties. The green synthesis of magnesium oxide nanoparticles (GS-MgONPs) can create an optimal prospect that is safe with low toxicity in biological tissue and better safety for application while including the antibacterial effect. This recent study aimed to evaluate the effectiveness of burn wound treatment using GS-MgONPs in rats.
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