AI Article Synopsis
- Senescence and autophagy are crucial for maintaining cellular balance, but both can lead to degenerative issues like oxidative stress and DNA damage.
- The relationship between autophagy and senescence is complex, as elevated autophagy can cause cell death, while insufficient autophagy may lead to cellular senescence.
- This review focuses on how both processes contribute to human diseases, including aging, kidney degeneration, neurodegenerative disorders, and cancer, by summarizing recent research on their interconnections.
Article Abstract
Senescence and autophagy play important roles in homeostasis. Cellular senescence and autophagy commonly cause several degenerative processes, including oxidative stress, DNA damage, telomere shortening, and oncogenic stress; hence, both events are known to be interrelated. Autophagy is well known for its disruptive effect on human diseases, and it is currently proposed to have a direct effect on triggering senescence and quiescence. However, it is yet to be proven whether autophagy has a positive or negative impact on senescence. It is known that elevated levels of autophagy induce cell death, whereas inadequate autophagy can trigger cellular senescence. Both have important roles in human diseases such as aging, renal degeneration, neurodegenerative disorders, and cancer. Therefore, this review aims to highlight the relevance of senescence and autophagy in selected human ailments through a summary of recent findings on the connection and effects of autophagy and senescence in these diseases.
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| http://dx.doi.org/10.1002/jcp.28895 | DOI Listing |
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