AI Article Synopsis
- The study aimed to explore the effects of combining desferrioxamine (DFO) and dextromethorphan (DXM) on Parkinson's disease symptoms in a rat model.
- By inducing Parkinson's using 6-hydroxydopamine, researchers assessed changes in behavior and neurobiochemical markers, finding that the combination treatment significantly improved motor symptoms and antioxidant enzyme levels while reducing harmful substances in the brain.
- The findings suggest that DFO and DXM may work together to protect dopamine neurons and mitigate symptoms of Parkinson's by reducing excitotoxicity and inflammation, indicating a potential therapeutic strategy for managing the disease.
Article Abstract
Objective: To investigate the effect of desferrioxamine (DFO) and dextromethorphan (DXM) combination in animal model of Parkinson's disease (PD).
Methods: The PD was induced in rats through intracerebroventricular administration of 6-hydroxydopamine (6-OHDA) using stereotaxic apparatus. The animals were subjected to behavioural assessments and neurobiochemicals estimation followed by immunohistochemistry staining of neuron specific enolase (NSE) in striatum.
Key Findings: Desferrioxamine and DXM combination has significantly reversed the catalepsy behaviour and elevated the antioxidant enzymes (SOD, CAT, GSH) and dopamine levels. Interestingly, the level of glutamate, nitric oxide, cytokines (IL-1β, TNF-α) and NSE expressions were found to be decreased in striatum region of 6-OHDA-administered rats. The combination of DFO and DXM has shown synergism in most of the parameters studied, when compared to per se treatment.
Conclusions: The reversal of catalepsy behaviour represents the protective effect of above combination on dopamine neurons in striatum from 6-OHDA toxicity. The mechanism of DFO and DXM combination might be attributed through attenuation of glutamate-induced excitotoxicity in neurons through ameliorating the reactive oxygen species and pro-inflammatory cytokines release. Treatment with DFO and DXM combination could control the multiple events in the pathogenesis of PD.
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| http://dx.doi.org/10.1111/jphp.13109 | DOI Listing |
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