Novel Immune Microlens Imaging for Detection of Antigen and Antibody.

J Immunol Res

Institute of Tissue Transplantation and Immunology, Department of Immunobiology, Jinan University, Guangzhou 510632, China.

Published: December 2019

Detection and analysis of antigen-antibody reaction is one of the most critical detection techniques in the fields of medicine, biology, environmental science, and food safety. Traditional and classical methods for detecting antigen and antibody encounter many problems, such as time-consuming, high cost, and low accuracy. A novel immune microsphere imaging technique by the microlens is used to test the changes of refractive index before and after antigen-antibody reaction. It can quickly perform qualitative and quantitative determination for antigen-antibody reaction without any labeling, premodification, postwashing, and expensive enzymes. Here, we feature and discuss its principle and advantages, structure of a microlens immunoassay instrument, and potential in measuring clinical samples. It is promising to be developed for application to diagnosis of clinical diseases.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501428PMC
http://dx.doi.org/10.1155/2019/5474519DOI Listing

Publication Analysis

Top Keywords

antigen-antibody reaction
12
novel immune
8
antigen antibody
8
immune microlens
4
microlens imaging
4
imaging detection
4
detection antigen
4
antibody detection
4
detection analysis
4
analysis antigen-antibody
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!