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Article Abstract
Objective: Neural tube defects (NTDs) are congenital disorders that significantly increase the risk of death and disability in the 1 year of life. The aim of this study was to retrospectively evaluate the patients admitted to our neonatal intensive care unit because of NTD.
Materials And Methods: We retrospectively examined the demographic features, familial risk factors, physical examination and radiological findings, and accompanying diseases of 69 patients with NTD.
Results: Of the 69 patients hospitalized in a 5-year period, 38 were female and 31 were male. The median birth weight was 3150 g and the median delivery week was 38 weeks. Forty-nine of the patients (71%) had meningomyelocele, 11 patients (16%) had encephalocele, and nine patients (13%) had meningocele. Forty-five of the patients (65.2%) had Arnold-Chiari type 2 malformation. Twenty-five percent of the mothers had a history of periconceptional use of folic acid. The median time of making a diagnosis of NTD by prenatal ultrasonography was 20 (16-24) weeks. Thirty-nine of the patients (56.5%) had other organ disorders, some with multiple systemic disorders.
Conclusion: The use of periconceptional folic acid in mothers and a decision for termination in selected cases may be effective in reducing the frequency of NTD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516008 | PMC |
| http://dx.doi.org/10.4103/ajns.AJNS_300_18 | DOI Listing |
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