AI Article Synopsis
- Stabilized HIV-1 envelope glycoproteins (Env) resembling the native form are being developed for vaccines to induce broadly neutralizing antibodies (bNAbs).
- A new SOSIP trimer was created using a consensus sequence of all HIV-1 group M isolates, showcasing most known bNAb epitopes and some germline precursor ones.
- The ConM trimer has shown to provoke strong neutralizing antibody (NAb) responses in animals, especially when delivered using ferritin nanoparticles, suggesting that consensus-based immunogens could aid in designing effective HIV-1 vaccines.
Article Abstract
Stabilized HIV-1 envelope glycoproteins (Env) that resemble the native Env are utilized in vaccination strategies aimed at inducing broadly neutralizing antibodies (bNAbs). To limit the exposure of rare isolate-specific antigenic residues/determinants we generated a SOSIP trimer based on a consensus sequence of all HIV-1 group M isolates (ConM). The ConM trimer displays the epitopes of most known bNAbs and several germline bNAb precursors. The crystal structure of the ConM trimer at 3.9 Å resolution resembles that of the native Env trimer and its antigenic surface displays few rare residues. The ConM trimer elicits strong NAb responses against the autologous virus in rabbits and macaques that are significantly enhanced when it is presented on ferritin nanoparticles. The dominant NAb specificity is directed against an epitope at or close to the trimer apex. Immunogens based on consensus sequences might have utility in engineering vaccines against HIV-1 and other viruses.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541627 | PMC |
| http://dx.doi.org/10.1038/s41467-019-10262-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!