AI Article Synopsis
- * The study involved 107 patients and found a high overall recurrence rate of 66.3%, with better performance of DKI in terms of sensitivity and specificity compared to DWI after RFA.
- * Results indicated that MK (a parameter from DKI) was the most sensitive predictor of recurrence, outperforming other measures like ADC and MD.
Article Abstract
Objective: This study aimed to compare the diffusion kurtosis imaging (DKI) versus diffusion weighted imaging (DWI) in predicting the recurrence of early stage single nodules of hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA).
Materials And Methods: A retrospective analysis of 107 patients with early stage single nodules of HCC was performed, all patients treated by RFA. Recurrence rate of HCC was recorded after a median follow-up of 36 months. During follow-up, the data of magnetic resonance imaging (MRI), DWI and DKI were obtained in multiple time points. The predictive values of DWI and DKI were analyzed using ROC curves.
Results: The overall recurrence rate was 66.3% (71/107). The sensitivity, specificity, and AUC for ADC, MD and MK after RFA (78.6, 73.3% and 0.842; 85.7, 83.3% and 0.839; 85.7, 96.7% and 0.956) were higher than before RFA (44.3, 53.3% and 0.560; 51.2, 56.7% and 0.543; 43.6, 67.3% and 0.489). The sensitivity, specificity, and AUC for MK after RFA were 85.7, 96.7%, and 0.956, respectively, which were significantly greater than those of ADC (78.6, 73.3% and 0.842; P < 0.05) and MD (85.7, 83.3% and 0.839).
Conclusions: The prediction efficacy of DKI for the recurrence of early stage single nodules of HCC was better than that of DWI. And, MK was the most sensitive predictor among the DKI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542145 | PMC |
| http://dx.doi.org/10.1186/s40644-019-0213-9 | DOI Listing |
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