The relationship between c-reactive protein gene +1444C/T, 3407T/C polymorphisms and colorectal cancer susceptibility.

Aim: The present study was conducted to analyze the relationship between c-reactive protein (CRP) gene +1444C/T, 3407T/C (rs2808630) polymorphisms and colorectal cancer susceptibility.

Methods: A total of 142 colorectal cancer patients and 127 healthy controls were recruited into this case-control study. The genotypes of CRP gene +1444C/T, rs2808630 polymorphisms were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and the genotypes distributions of polymorphisms in controls was assessed whether conformed to Hardy-Weinberg equilibrium (HWE). The calculation of odds ratio (OR) with its 95% confidence interval (95% CI) is used for evaluating the association strength of gene polymorphism and disease.

Results: Through the testing of χ, the genotypes distributions were consistent with HWE in the control group. We identified that only CC genotype frequency in CRP rs2808630 had a significant difference in cases and controls (P = 0.03) and people who carried CC genotype had a low risk suffering from colorectal cancer, compared with TT genotype carriers (OR = 0.35, 95% CI = 0.14-0.90). However, the other genotypes in rs2808630 and even the genotypes CRP +1444C/T polymorphism were all not associated with the generation of colorectal cancer.

Conclusion: CRP rs2808630 polymorphism was related to the decreased risk of colorectal cancer, but not +1444C/T polymorphism.