AI Article Synopsis
- - During pregnancy, maternal regulatory T cells (Tregs) play a crucial role in creating immune tolerance to fetal cells, specifically extravillous trophoblasts (EVTs), with CD25FOXP3+ Tregs being prevalent in the decidua.
- - This study identifies three unique decidual CD4+ Treg types—CD25FOXP3+, PD1IL-10+, and TIGIT+FOXP3—all of which have the capacity to suppress immune responses.
- - Co-culturing HLA-G+ EVTs or decidual macrophages with maternal blood CD4+ T cells boosts the levels of CD25FOXP3+ Tregs and indicates a specific immune response influenced by antigens like
Article Abstract
During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune tolerance to invading fetal extravillous trophoblasts (EVTs). CD25FOXP3+ Tregs are found at high levels in decidual tissues and have been shown to suppress fetus-specific and nonspecific responses. However, limited data are available on additional decidual Treg types and the mechanisms by which they are induced. This study investigated three distinct decidual CD4+ Treg types in healthy pregnancies with a regulatory phenotype and the ability to suppress T cell responses: CD25FOXP3+, PD1IL-10+, and TIGIT+FOXP3. Moreover, co-culture of HLA-G+ EVTs or decidual macrophages with blood CD4+ T cells directly increased the proportions of CD25FOXP3+ Tregs compared to T cells cultured alone. EVTs also increased PD1 Tregs that could be inhibited by HLA-C and CD3 antibodies, suggesting an antigen-specific induction. The presence of distinct Treg types may allow for the modulation of a variety of inflammatory responses in the placenta.
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| http://dx.doi.org/10.1016/j.celrep.2019.04.109 | DOI Listing |
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