Fractionation of extracts from the culture broth of the marine-derived fungus, sp. 7A22, resulted in the isolation of the harzialactone A (), a known compound previously isolated from fungi of marine environments. The chemical structure of was determined by spectroscopic analyses. Upon evaluation of on antileishmanial assays against , exhibited significant activity against promastigotes forms with IC of 5.25 µg mL and moderate activity against intracellular amastigotes with IC of 18.18 µg mL. This is the first report on the antileishmanial activity of , and the effects of presented in this work suggest that this class of compounds are suitable for future biological and studies for the search of natural products with activity against spp. Furthermore, the present results corroborate marine-derived fungi as a promising source of natural products with antiparasitic activity.
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| http://dx.doi.org/10.1080/14786419.2019.1619725 | DOI Listing |
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