The Federal Republic of Germany was the last European Country without a drug legislation and a law about drug advertising until the 1960s. Therefore, a broad medical subculture flourished. Various dealers sold drugs and instruments for curing psychosomatic illnesses, especially anti-impotence pills or aids to reduce weight. Thus, the interested client could treat himself/herself without visiting a physician or a pharmacy. Some physicians tried to reduce this grey market, but they were not successful.
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http://dx.doi.org/10.1007/s00120-019-0961-y | DOI Listing |
EXCLI J
November 2024
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43B, 07100 Sassari, Italy.
The p53-MDM2 pathway plays a crucial role regulating tumor suppression and is a focal point of cancer research. This literature review delves into the complex interplay between the tumor suppressor protein p53 and its main regulator MDM2, highlighting their interaction and implications in cancer development and progression. The review compiles and summarizes the existing understanding of the biology and regulation of p53 and MDM2, emphasizing their roles in various cellular processes, including cell cycle regulation, DNA repair, apoptosis, and metabolism.
View Article and Find Full Text PDFJ Anim Physiol Anim Nutr (Berl)
January 2025
Centre for Animal Nutrition and Welfare, University of Veterinary Medicine, Vienna, Austria.
Increasing droughts adversely affect grasslands, diminishing the availability and quality of forages for ruminants. We have recently shown that mixed ensiling of drought-impaired grass (DIG) with sugar beet pulp (SBP) improved the conservation and feed value of silage. The application of silage additives may further improve the ruminal degradability, which may thereby shape the fermentation and microbiome in the rumen when those silages are tested as part of dairy diets.
View Article and Find Full Text PDFPlanta
January 2025
Normandie Université, UNICAEN, INRAE, UMR 950 Ecophysiologie Végétale, Agronomie Et Nutritions N, C, S, Esplanade de La Paix CS14032, 14032, Caen Cedex 5, France.
The effects of intense heat during the reproductive phase of two Brassica species-B. napus and C. sativa-could be alleviated by a prior gradual increase exposure and/or PGPR inoculation.
View Article and Find Full Text PDFJ Paleolit Archaeol
July 2024
Laboratory of Theriology, Zoological Institute of the Russian Academy of Sciences, St. Petersburg, Russian Federation.
The Altai mountains contain a number of cave and rockshelter sites that have given crucial information about human evolution in Asia. Most of these caves are located in the Gornyi Altai of Siberia, while the southern flank of the range remains much less known. Bukhtarma Cave was a karstic cave located near the former village of Peshchera, on the banks of the Bukhtarma River running through the foothills of the southern (Kazakh) Altai mountains.
View Article and Find Full Text PDFPhys Occup Ther Pediatr
January 2025
Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
Aims: To evaluate attendance rates, daily therapy engagement, parents' perceptions regarding feasibility, acceptability, family-centeredness, and individualized outcomes of a collaborative telehealth-based physical therapy intervention for children with disabilities.
Method: Mixed-method design involving 15 families and 17 children with disabilities (range age 4-90 months). Parents recorded time spent on home activities.
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