Objective: Cognitive impairment is an important symptom of Parkinson's disease (PD) and seriously affects patients' quality of life and prognosis. However, its cause is still uncertain. In about one-third of patients, PD is associated with rapid eye movement sleep behavior disorder (RBD), which is an independent risk factor for PD-associated dementia; but whether or not it relates to the cognitive function of patients with nondemented PD is still controversial.
Methods: The data from 89 enrolled PD patients were retrospectively analyzed. The RBD Questionnaire Hong-Kong (RBD-HK) was used to diagnose possible RBD (pRBD). There are 46 patients with possible RBD (the PD-pRBD) and 43 without (the PD-npRBD). PD disease severity, neuropsychological function, overall cognitive function, and various cognitive functions were assessed.
Results: There were significant between-group differences in scores on the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Digit Symbol Test (DST), Trail Making Test-A (TMT-A)-Time, TMT-Trail Making Test-B (TMT-B)-Time, Stroop Color-word Test, Clock Drawing Test (CDT), Boston Naming Test (BNT), Verbal Fluency Test (fruit), etc. ( < 0.05).
Interpretation: Patients in the PD-pRBD group had more cognitive impairment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529834 | PMC |
| http://dx.doi.org/10.1002/acn3.747 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Growing up with a brother or sister with Down syndrome: Adult siblings' perceptions of their childhood relationships.
J Intellect Dev Disabil
March 2022
Department of Educational Psychology, Université de Lorraine (2LPN: Laboratoire Lorrain de Psychologie and Neurosciences de la dynamique des comportements - EA 7489).
Background: The increased life expectancy of people with Down syndrome puts pressure on parents, who are usually the main caregivers but who find caring more difficult as they get older. The quality of the support provided by brothers and sisters depends on the intra-family relationships they build when growing up.
Methods: 121 adult siblings of people with Down syndrome completed a questionnaire on their perceptions of their childhood relationships.
What does the French public think about inclusive education?
J Intellect Dev Disabil
December 2021
Trisomie 21 France, Saint-Etienne, France.
Background: To explain that students with intellectual disabilities are not fully included in mainstream education, the present paper investigates public attitudes towards inclusive education and notably examines how these vary according to students' type of disability (i.e., an intellectual, a communicational, a sensory, a motor, or a specific learning one).
View Article and Find Full Text PDFSusceptibility to peer influence in adolescents with mild-to-borderline intellectual disability: Investigating links with inhibition, Theory of Mind and negative interpretation bias.
J Intellect Dev Disabil
December 2022
Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Background: This preregistered study compares adolescents with mild-to-borderline intellectual disability (MBID) and typically developing (TD) adolescents on their susceptibility to peer influence. To understand why adolescents with MBID are susceptible to peer influence, links with inhibition, Theory of Mind (ToM) and negative interpretation bias are investigated.
Method: We assessed 163 adolescents (111 MBID, 52 TD 14-19 years; 63% boys) using experimental tasks and self- and/or teacher-reports.
Lateralization of the Aberrant Amplitude of Low-Frequency Fluctuation within the Default Mode Network in Patients with Mild Cognitive Impairment.
Acad Radiol
January 2025
Department of Radiology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China (Q.X.). Electronic address:
Rationale And Objectives: Alzheimer's disease (AD) is the most common pathogenesis of dementia, and mild cognitive impairment (MCI) is considered as the intermediate stage from normal elderly to AD. Early detection of MCI is an essential step for the timely intervention of AD to slow the progression of this disease. Different form previous studies in the whole-brain spontaneous activities, this research aimed to explore the low-frequency amplitude spectrum activities of patients with MCI within the default mode network (DMN), which has been involved in the process of maintaining normal cognitive function.
View Article and Find Full Text PDFWhat is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? - A systematic review.
Eur J Intern Med
January 2025
Universidade Católica Portuguesa, Católica Medical School, Sintra, Portugal.
Cognitive impairments are frequently observed in patients with Alcohol Use Disorder (AUD). Thiamine deficiency is often found in AUD patients and has been suggested as a possible cause of cognitive impairments. While thiamine deficiency is not consistently present in all AUD patients with cognitive deficits, thiamine is traditionally prescribed to patients with AUD to treat or prevent cognitive impairment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!