AI Article Synopsis
- Gold is a highly effective metal for organometallic catalysis due to its ability to activate unsaturated groups and its compatibility with various functional groups and reaction conditions.
- The review focuses on how gold(I) and gold(III) catalysts facilitate intramolecular (cyclo)isomerization reactions, which help create complex molecular structures often found in natural products and pharmaceuticals.
- Recent advancements in using gold catalysts are categorized based on the substrate and type of reaction, particularly highlighting reactions involving allene or alkyne motifs.
Article Abstract
Gold is currently one of the most used metals in organometallic catalysis. The ability of gold to activate unsaturated groups in different modes, together with its tolerance to a wide range of functional groups and reaction conditions, turns gold-based complexes into efficient and highly sought after catalysts. Natural products and relevant compounds with biological and pharmaceutical activity are often characterized by complex molecular structures. (Cyclo)isomerization reactions are often a useful strategy for the generation of this molecular complexity from synthetically accessible reactants. In this review, we collect the most recent contributions in which gold(I)- and/or gold(III)-catalysts mediate intramolecular (cyclo)isomerization transformations of unsaturated species, which commonly feature allene or alkyne motifs, and organize them depending on the substrate and the reaction type.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527766 | PMC |
| http://dx.doi.org/10.3389/fchem.2019.00296 | DOI Listing |
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