Surgical site infections (SSIs) are commonly caused by We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of SSI. Therefore, monoclonal antibody-based neutralization of multiple virulence factors may provide an adjunctive perioperative approach to combat SSIs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658795 | PMC |
| http://dx.doi.org/10.1128/AAC.00346-19 | DOI Listing |
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