Electronic medical records (EMRs), such as hospital discharge summaries, contain a wealth of information only expressed in natural language. Automated methods for extracting information from these records must be able to recognize medical concepts in text and their semantic context. A contextual property critical to reason on information from EMRs is the doctor's belief status or assertion of the patient's medical problem. Research on the medical assertion classification (MAC) can establish the foundation for various health data analyses and clinical applications. However, previous MAC studies are mainly based on traditional machine learning methods which mostly require manually constructed features and the original unlabeled data cannot be easily and effectively applied to classification or classification tasks. Furthermore, external medical knowledge such as various medical dictionary bases, which provides rich explain and definition information about medical entity, is rarely utilized in existing neural network models of medical information extraction. In this study, we propose a deep neural network architecture enhanced by medical knowledge attention layer through combining GRU neural network with CNN model to classify the assertion type of medical problem such as disease and symptom in Chinese EMRs. The attention layer in the model is applied to integrate entity representations learned from medical dictionary bases as query for encoding. Experimental results on own manually annotated corpus indicate our approach achieves better performance compared to existing methods.
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http://dx.doi.org/10.3934/mbe.2019096 | DOI Listing |
J Environ Qual
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College of Science, Inner Mongolia University of Technology, Hohhot, China.
Climate change, driven by greenhouse gas emissions, has emerged as a pressing global ecological and environmental challenge. Our study is dedicated to exploring the various factors influencing greenhouse gas emissions from animal husbandry and predicting their future trends. To this end, we have analyzed data from China's Inner Mongolia Autonomous Region spanning from 1978 to 2022, aiming to estimate the carbon emissions associated with animal husbandry in the region.
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March 2025
School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China.
The self-assemblies of topological complex block copolymers, especially the AB type miktoarm star ones, are fascinating topics in the soft matter field, which represent typical self-assembly behaviors analogous to those of biological membranes. However, their diverse topological asymmetries and versatile spontaneous curvatures result in rather complex phase separations that deviate significantly from the common mechanisms. Thus, numerous trial-and-error experiments with tremendous parameter space and intricate relationships are needed to study their assemblies.
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March 2025
Ophthalmic Genetics & Visual Function Branch, National Eye Institute, Bethesda, Virginia, USA.
The development of the neural retina requires a complex, spatiotemporally regulated network of gene expression. Here we review the role of the cone rod homeobox () transcription factor in specification and differentiation of retinal photoreceptors and its function in inherited retinal diseases such as cone-rod dystrophy (CoRD), dominant retinitis pigmentosa (RP), and Leber's congenital amaurosis (LCA). We delineate the findings of animal models and, more recently, human retinal organoids in elucidating molecular mechanisms of CRX activity and the pathogenesis of inherited photoreceptor degenerations.
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March 2025
Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
The capacity for language constitutes a cornerstone of human cognition and distinguishes our species from other animals. Research in the cognitive sciences has demonstrated that this capacity is not bound to speech but can also be externalized in the form of sign language. Sign languages are the naturally occurring languages of the deaf and rely on movements and configurations of hands, arms, face, and torso in space.
View Article and Find Full Text PDFHandb Clin Neurol
March 2025
Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Electronic address:
The lateralization of language to the left hemisphere of the human brain constitutes one of the classic examples of asymmetry in biology. At the same time, it is also commonly understood that damage to the left hemisphere does not lead to a complete loss of all linguistic abilities. These seemingly contradictory findings indicate that neither our cognitive capacity for language nor its neural substrates are monolithic.
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