Oxidative stress has been identified as an underlying factor in the development of insulin resistance, β-cell dysfunction, impaired glucose tolerance and type 2 diabetes mellitus and it also play major role in kidney stone formation. The present study is aimed to elucidate the nephroprotective activity of two isoflavonoid glycosides, tectorigenin 7-β-D-glucosyl-(1→6)-β-D-glucoside () and tectorigenin 7--β-D-glucosyl-4'--β-D-glucoside () isolated from the -BuOH fraction of L. (Zeal) rhizome MeOH extract against oxalate and high glucose-induced oxidative stress in NRK-49F cells. The results revealed that compounds and significantly increased the antioxidant enzyme activities and decreased MDA levels in both oxalate and high glucose stress. Treatment with these phytochemicals effectively down-regulated expression of crystal modulator genes and pro-fibrotic genes in oxalate and high glucose-mediated stress respectively. This study indicates cytoprotective, antioxidant, anti-urolithic and anti-diabetic effects of compounds and against oxalate and high glucose stress.[Figure: see text].
The recycling of critical metals from spent lithium-ion batteries represents a significant step towards meeting the enhancing resource requirements in the new energy industry. Nevertheless, achieving effective leaching of metals from the stable metal-oxygen (MO6) structure of spent ternary cathodes and separation of metal products simultaneously still remained a huge challenge towards industrial applications. Herein, a competitive coordination strategy was proposed to design a novel deep eutectic solvent (DESs), which improved both leaching and selective metal recycling capacity even at high solid-liquid ratio (1:10).
The current study's initial goal was to investigate the anticancer activity of the extracts from the flowering plant Nyctanthes arbor-tristis. The ethanol extracts' phytochemical analysis was qualitatively determined. It was determined that the various phytochemical substances had antibacterial, antioxidant, and anticancer effects.
In calcium stone formers, most stones grow attached to Randall's plaque, which can be identified by measuring the computed tomography (CT) attenuation value of renal papilla. We hypothesized that the CT attenuation value of renal papilla can predict the severity (recurrent or multiple stone former) and recurrence of the stone disease. We retrospectively reviewed the charts of 180 calcium oxalate stone formers who underwent non-contrast CT and 24-hour urine chemistry in our hospital between September 2012 and November 2021.
Instituto de Energías Renovables, Universidad Nacional Autónoma de México (IER-UNAM). Priv. Xochicalco S/N, Col. Centro, Temixco, Morelos, 62580, Mexico.
The Electro-Fenton process (EF) has been conventionally applied to efficiently degrade refractory and/or toxic pollutants. However, in this work, EF was used as a reverse engineering tool to selectively synthesize highly value-added products (oxalic or oxamic acid) through the degradation of the model pollutant acetaminophen, a widely used analgesic and antipyretic drug. It was found that the production of either oxalic or oxamic acid is dictated by the applied current density.
Background: The calcium-sensitive receptor (CaSR) has been identified as a key factor in the formation of kidney stones. A substantial body of research has illuminated the function of CaSR in stone formation with respect to oxidative stress, epithelial injury, crystal adhesion, and stone-associated proteins. Nevertheless, as a pivotal molecule in renal calcium excretion, its pathway that contributes to stone formation by regulating calcium supersaturation remains underexplored.
