Histone lysine methyltransferases (KMTs) are biomedicinally important class of epigenetic enzymes that catalyse methylation of lysine residues in histones and other proteins. Enzymatic and computational studies on the simplest lysine analogues that possess a modified main chain demonstrate that the lysine's backbone contributes significantly to functional KMT binding and catalysis.
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Hereditas
January 2025
Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Provincie & Hainan Provincial Clinical Research Center for Thalassemia, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, 571101, China.
Background: The dynein cytoplasmic two heavy chain 1 (DYNC2H1) gene encodes a cytoplasmic dynein subunit. Cytoplasmic dyneins transport cargo towards the minus end of microtubules and are thus termed the "retrograde" cellular motor. Mutations in DYNC2H1 are the main causative mutations of short rib-thoracic dysplasia syndrome type III with or without polydactyly (SRTD3).
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Key Laboratory of State Administration of Traditional Chinese Medicine, Dongguan HEC Cordyceps R&D Co., Ltd., Dongguan, Guangdong 523850, China; College of Medical Imaging Laboratory and Rehabilitation, Xiangnan University, Chenzhou, Hunan 423000, China. Electronic address:
Cultivated Chinese cordyceps, an optimal substitute for the endangered wild resource, has recently been produced on a large scale. This work sought to explore the structural features and immunomodulatory activity of a novel low-molecular-weight polysaccharide (CSP1a, 15.7 kDa) isolated from cultivated Chinese cordyceps.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address:
Steamed Polygonatum sibiricum is widely applied in clinical practice for its tonic effect on gastrointestinal tract. A novel polysaccharide named PSSP-EF was extracted from the steamed roots of Polygonatum sibiricum using hot water extraction, ethanol precipitation, and chromatographic purification. PSSP-EF, with a molecular weight of 2.
View Article and Find Full Text PDFPLoS One
January 2025
School of Management, Xi'an Polytechnic University, Xi'an, Shaanxi, China.
This article compares the population agglomeration characteristics of the Xi'an metropolitan area in western China with those of metropolitan areas in other regions officially approved by the Chinese government. The kernel density estimation method and Markov chain model were used to conduct the study. The results revealed that from 2010 to 2020, the population agglomeration level of the Xi'an metropolitan area showed a trend of first increasing and then decreasing.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
ShanghaiTech University, School of Physicl Science and Technology, 393 Middle Huaxia Road, Pudong, Shanghai, 201210, Shanghai, CHINA.
Traditionally, α-olefins have been regarded as non-homopolymerizable substrates in textbook examples. However, they have the ability to copolymerize with sulfur dioxide, leading to the creation of alternating copolymers. These commodity poly(olefin sulfone)s exhibite a wide array of applications.
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