Objective: To evaluate the clinical performance of Glass Carbomer (GC) (GCP Dental) in restoring Class II cavities in primary molars in comparison with resin-modified glass-ionomer cement (RMGIC) and composite resin (CR) restorations.
Method And Materials: Healthy children aged between 4 and 8 years with a proximal lesion in at least one primary molar were recruited from the Pediatric Dental Clinics. A sample of 162 molars was randomly assigned to one of the following restoration types: GC, RMGIC, and CR. The restorations were evaluated clinically using the Cvar and Ryge criteria at 6 and 12 months postoperatively.
Results: At 12 months, the success rates of anatomical form and marginal adaptation were 67% and 54% for GC, 98% and 93% for RMGIC, and 98% and 98% for CR, respectively. The GC restorations were significantly less successful than RMGIC and CR restorations in terms of anatomical form (P < .001) and marginal adaptation (P < .001). Secondary caries formation was not observed in any of the restorations in the three restorative material groups.
Conclusion: The 12-month clinical performance of the GC restorative material was not satisfactory in restoring Class II cavities in primary molars. RMGIC and composite resin restorations performed significantly better. The use of GC cannot be recommended for restoring Class II cavities in primary molars.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.3290/j.qi.a42573 | DOI Listing |
J Am Chem Soc
January 2025
Warshel Institute for Computational Biology, School of Life and Health Sciences, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China.
The parathyroid hormone type 1 receptor (PTH1R) plays a crucial role in modulating various physiological functions and is considered an effective therapeutic target for osteoporosis. However, a lack of detailed molecular and energetic information about PTH1R limits our comprehensive understanding of its activation process. In this study, we performed computational simulations to explore key events in the activation process, such as conformational changes in PTH1R, Gs protein coupling, and the release of guanosine diphosphate (GDP).
View Article and Find Full Text PDFAnal Chim Acta
February 2025
Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing, 100081, China. Electronic address:
Background: The metal organic cages (MOCs) are an emerging type of porous material that has attracted considerable research interest due to their unique properties, including good stability and well-defined intrinsic cavities. The chiral MOCs with porous structures have broad application prospects in enantiomeric recognition and separation. However, there are almost no relevant reports on chiral MOCs as chiral stationary phases (CSPs) for enantioseparation by high-performance liquid chromatography (HPLC).
View Article and Find Full Text PDFMol Divers
January 2025
School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, People's Republic of China.
The p53 protein is regarded as the "Guardian of the Genome," but its mutation is tumor progression and present in more than half of malignant tumors. The pro-metastatic property of mutant p53 makes a strong argument for targeting mutant p53 with new therapeutic strategies. However, mutant p53 was considered as a challenging target for drug discovery due to the lack of small molecular binding pockets.
View Article and Find Full Text PDFPolymers (Basel)
December 2024
Key Laboratory of State Forestry Administration for Silviculture of the Lower Yellow River, College of Forestry, Shandong Agricultural University, Tai'an 271018, China.
Paper-based packaging materials have gained attention from academia and industry for their outstanding environmental sustainability advantages. However, they still encounter major challenges, such as low mechanical strength and inadequate functionality, hindering the replacement of unsustainable packaging materials. Inspired by the remarkable strength of trees provided by cellulose fibers and the water and heat protection of trees provided by bark, this study developed a new biomass-based packaging material (SNC-C) that combines strength, thermal insulation, and water resistance.
View Article and Find Full Text PDFSci Rep
January 2025
Conservative Dentistry Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
The main objective of the current study is to compare short-term fluoride release of three ion releasing restorative materials and assess their inhibitory effect on secondary caries. Materials used in this study included, Self-adhesive hybrid composite (group A), Ion releasing flowable composite liner (group B), and alkasite restorative material (group C). Twenty-two discs were fabricated from each material for short-term fluoride release test, conducted on days 1, 7, and 14.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!