CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations. To determine the relation between CSF protein concentrations and brain volume. Brain volumes (total intracranial, gray matter, white matter volumes) derived from brain MRI and CSF protein concentrations (total protein, albumin, albumin CSF/serum ratio) of 29 control patients and 497 patients with clinically isolated syndrome or multiple sclerosis were studied. We found significant positive correlations of CSF protein concentrations with intracranial, gray matter, and white matter volumes. None of the correlations remained significant after correction for age and sex. Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF.
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| http://dx.doi.org/10.3389/fneur.2019.00463 | DOI Listing |
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