This is a scoping review of the notions of authenticity and citizenship in the context of understanding dementia. Authenticity suggests being true to yourself. Social citizenship suggests engagement, relationships and rights. The literature which links authenticity to dementia is scanty, albeit the notion suggests numerous possibilities. The literature on citizenship and dementia is more extensive. After some conceptual discussion, the literature is reviewed. The authenticity literature focuses on people being themselves, on partnerships and on decision-making. There is also literature on how carers of people living with dementia might be more authentic or genuine. Over against the possibility that the demands of citizenship might swamp the drive to individual authenticity, the review shows that, in line with authenticity being a social virtue, it is implied or conveyed by much of the literature on citizenship, in particular by the characterization of citizenship in terms of coherence (and thus narrative), vitality, maturity and depth.
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http://dx.doi.org/10.1016/j.maturitas.2019.04.001 | DOI Listing |
J Nat Prod
December 2024
Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
is an edible and medicinal mushroom. Previously, we found hericenones C-H from the fruiting bodies and erinacines A-I from the mycelia of the fungus. These compounds stimulated nerve growth factor (NGF) synthesis both and ; some have been suggested to be effective in the prevention and treatment of dementia.
View Article and Find Full Text PDFNihon Yakurigaku Zasshi
November 2024
Department of Pharmacology, Kochi Medical School, Kochi University.
Amyloid-β (Aβ) 42, one of the causes of Alzheimer's disease (AD), is produced by the cleavage of amyloid precursor protein (APP) by β- or γ-secretases. Since Aβ42 oligomers exhibit strong neurotoxicity, Aβ42 is predicted to be a potentially efficient target for drug therapies. Recently, we screened peptides that activate MMP7 using our peptide library and found that the synthetic peptide JAL-TA9 (YKGSGFRMI), which is derived from the BoxA region of Tob1 protein, showed proteolytic activity.
View Article and Find Full Text PDFArtif Intell Health
July 2024
Department of Epidemiology and Biostatistics, College Park, University of Maryland School of Public Health, District of Columbia, United States of America.
Alzheimer's disease and related dementias (ADRD) are a spectrum of disorders characterized by cognitive decline, which pose significant challenges for both affected individuals and their caregivers. Previous literature has focused on patient family surveys which do not always capture the breadth of authentic experiences of the caregiver. Online social media platforms provide a space for individuals to share their experiences and obtain advice toward caring for those with ADRD.
View Article and Find Full Text PDFJ Huntingtons Dis
September 2024
Human Brain & Tissue Bank, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background: Diffusion magnetic resonance imaging (dMRI) has revealed microstructural changes in white matter (WM) in Huntington's disease (HD).
Objective: To compare the validities of different dMRI, i.e.
Int J Mol Sci
June 2024
Neuro-Bio Ltd., Building F5 The Culham Campus, Abingdon OX14 3DB, UK.
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no effective treatments, not least due to the lack of authentic animal models. Typically, rodent models recapitulate the effects but not causes of AD, such as cholinergic neuron loss: lesioning of cholinergic neurons mimics the cognitive decline reminiscent of AD but not its neuropathology. Alternative models rely on the overexpression of genes associated with familial AD, such as amyloid precursor protein, or have genetically amplified expression of mutant tau.
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