AI Article Synopsis
- The study aimed to evaluate the effectiveness of using both systemic and local methotrexate to treat cesarean scar pregnancies and to compare it with data from related cases.
- The research involved a review of 12 patients treated at a university hospital between 2014 and 2018, all of whom successfully received the combined methotrexate treatment without needing surgery and experienced minimal side effects.
- Results showed that while the treatment duration was longer than other methods, it was safe, preserved fertility, and had a high success rate, with patients taking an average of 98 days to normalize hormone levels post-treatment.
Article Abstract
Objective: To report the efficacy of combined systemic and local methotrexate treatment for cesarean scar pregnancy and review data from selected, similar case series.
Study Design: A retrospective case series of 12 patients with cesarean scar pregnancy treated in a university hospital between 2014 and 2018. The intervention was combined treatment of systemic and local methotrexate.
Results: Twelve patients were treated with combined systemic and local methotrexate. Clinical characteristics, clinical course and treatment efficacy were evaluated. Mean gestational age at diagnosis was 7.5 weeks (range 5.9-9.1). βhCG levels at diagnosis ranged from 1581 to 345,427 U/L with a mean of 77,795 U/L. All 12 patients were successfully treated without surgical intervention and with no significant side-effects. Mean hospitalization duration was 9 days (5.8-12.6) and mean time to normalization of βhCG levels was 98 days (63-132).
Conclusions: Treatment of cesarean scar pregnancy with a combination of systemic and local methotrexate was effective and safe. Although the treatment course tends to be longer than with other modalities, this protocol offers excellent success rates, with fertility preservation and few complications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejogrb.2019.05.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development and internal validation of a model predicting successful trial of labour among pregnant individuals with previous one caesarean section: A cohort study (DEVI-CS model).
Eur J Obstet Gynecol Reprod Biol
December 2024
Department of Obstetrics & Gynaecology, Jawaharlal Institute of Medical Education & Research, Puducherry 605006, India. Electronic address:
Objective: To develop and internally validate a model predicting successful trial of labour among pregnant women with previous caesarean scar.
Design: Cohort study.
Setting: Tertiary care and teaching hospital.
Cord Blood Platelet-Rich Plasma in Cesarean Section Wound Management.
Obstet Gynecol Int
December 2024
Department of Integrative Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand.
Platelet-rich plasma (PRP) promotes the wound-healing process and reduces pain. Cord blood platelet-rich plasma (CB-PRP), which can be easily collected from the umbilical cord and reapplied to a cesarean section wound, has been proposed to have similar effects as PRP. This paper hypothesizes that CB-PRB would provide beneficial effects in terms of wound healing and pain reduction in women undergoing cesarean section.
View Article and Find Full Text PDFSonographic Assessment of Isthmocele and Its Obstetric Complications in Subsequent Pregnancies: A Pictorial Review.
Indian J Radiol Imaging
January 2025
Department of Pediatrics, St. John's Medical College, Bengaluru, Karnataka, India.
Cesarean scar defect represents a significant pathology attributed to the rising prevalence of cesarean deliveries. While not commonplace, these lesions can give rise to severe obstetric consequences during subsequent pregnancies. Given the potential complications, it is advisable to screen for uterine niches using transvaginal ultrasound (TVUS) or contrast-enhanced TVUS for individuals planning to conceive.
View Article and Find Full Text PDFRisk of intraoperative hemorrhage during cesarean scar ectopic pregnancy surgery: development and validation of an interpretable machine learning prediction model.
EClinicalMedicine
December 2024
Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, China.
Background: Current models for predicting intraoperative hemorrhage in cesarean scar ectopic pregnancy (CSEP) are constrained by known risk factors and conventional statistical methods. Our objective is to develop an interpretable prediction model using machine learning (ML) techniques to assess the risk of intraoperative hemorrhage during CSEP in women, followed by external validation and clinical application.
Methods: This multicenter retrospective study utilized electronic medical record (EMR) data from four tertiary medical institutions.
Current surgical treatment of uterine isthmocele: an update of existing literature.
Arch Gynecol Obstet
December 2024
Department of Obstetrics and Gynecology, Spital Männedorf, 8708, Männedorf, Switzerland.
The prevalence of uterine isthmocele, also known as a uterine niche, has risen in parallel with increasing cesarean section (CS) rates, affecting approximately 60% of women depending on their history of cesarean deliveries. This condition, now categorized as cesarean scar disorder (CSD) by the "Delphi consensus," is characterized by one primary or two secondary symptoms. Diagnosis can be made through transvaginal ultrasound, sonohysterography, hysteroscopy, or magnetic resonance imaging (MRI).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!