Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study.

Kevin L Steiner Mamun Kabir Jeffrey W Priest Biplob Hossain Carol A Gilchrist Heather Cook Jennie Z Ma Poonum S Korpe Tahmeed Ahmed A S G Faruque Rashidul Haque William A Petri

Clin Infect Dis

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville.

Published: January 2020

In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938969	PMC
http://dx.doi.org/10.1093/cid/ciz430	DOI Listing

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