Two new isopimarane diterpenoids, named 1-hydroxy-7-oxoisopimara-8, 15-diene (), 11-hydroxy-7-oxoisopimara-8(14), 15-diene (), together with six known compounds (), were isolated from the medicinal plant . All isolates were assayed for their cytotoxicity and -glucosidase inhibitory activity. Results suggested compounds , possessed significant cytotoxic activity against HepG2, HL60, and Hela cell lines with IC values ranging from 0.23 to 0.35 μM, and compounds , exhibited noticeable -glucosidase inhibitory ability with IC values of 0.25 and 0.31 μM, respectively.
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http://dx.doi.org/10.1080/10286020.2019.1618279 | DOI Listing |
Sci Rep
January 2025
Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al Mauz, P. O. Box 33, Nizwa, Oman.
Diabetes mellitus, particularly type 2 diabetes, is a growing global health challenge characterized by chronic hyperglycemia due to insulin resistance. One therapeutic approach to managing this condition is the inhibition of α-glucosidase, an enzyme involved in carbohydrate digestion, to reduce postprandial blood glucose levels. In this study, a series of thiosemicarbazide-linked quinoline-piperazine derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity, to identify new agents for type 2 diabetes management.
View Article and Find Full Text PDFTree Physiol
January 2025
Research Faculty of Agriculture, Hokkaido University, Sapporo, 060-8589, Japan.
Tree bark is a crucial tissue that defends tree stems from invasions by microorganisms. However, our understanding of the constitutive chemical defense mechanisms of the tree barks remains limited. Our group recently discovered that the inner bark of Sorbus commixta exhibited potent inhibitory effects on the growth of the white-rot fungus, Trametes versicolor.
View Article and Find Full Text PDFFood Sci Nutr
January 2025
Department of Plant Physiology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia University of Belgrade Belgrade Serbia.
(L.) Roxb. and (L.
View Article and Find Full Text PDFNat Prod Res
January 2025
College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Phytochemical investigation of the roots of yielded a new phenylpropanoid, adenophoride () and a new polyacetylene, adenylene () along with four phenylpropanoids and a polyacetylene. The structures were determined by spectroscopic analysis including NMR, MS, UV and IR. Among the isolated compounds, phenylpropanoids including a new compound showed mild α-glucosidase inhibitory activities.
View Article and Find Full Text PDFJ Sci Food Agric
January 2025
Department of Chemistry, Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi, Thailand.
Background: Edible insects are used for consumption and traditional medicine due to their rich bioactive compounds. This study examined the bioactive compounds and inhibitory effects of crude extracts from Bombyx mori and Omphisa fuscidentalis on α-glucosidase, α-amylase, acetylcholinesterase (AChE), and tyrosinase. Fatty acids, including n-hexadecanoic acid and oleic acid, were identified in the extracts and evaluated for their inhibitory potential against the enzymes in vitro and in silico.
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