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Cyclist safety assessment using autonomous vehicles.
Accid Anal Prev
January 2025
Department of Civil Engineering, The University of British Columbia, Canada.
Proactive and holistic safety management approaches should consider multi-modal crash risk. Cyclist crash risk should be prioritized given the high-severity of vehicle-cyclist crashes. Cyclist crash risk is difficult to quantify given the sparse nature of cyclist collisions and collisions in general.
View Article and Find Full Text PDFAn in-silico investigation of the effect of changing cycling crank power and cadence on muscle energetics and active muscle volume.
J Biomech
February 2025
School of Human Movement and Nutrition Sciences, University of Queensland, St Lucia Street, 4072 Brisbane, QLD, Australia; Faculty of Health. School of Exercise & Nutrition Sciences, Queensland University of Technology, 2 George St, Brisbane City, QLD 4000, Australia. Electronic address:
This study used musculoskeletal modelling to explore the relationship between cycling conditions (power output and cadence) and muscle activation and metabolic power. We hypothesized that the cadence that minimized the simulated average active muscle volume would be higher than the cadence that minimized the simulated metabolic power. We validated the simulation by comparing the predicted muscle activation and fascicle velocities with experimental electromyography and ultrasound images.
View Article and Find Full Text PDFPFENet: Towards precise feature extraction from sparse point cloud for 3D object detection.
Neural Netw
January 2025
School of Software Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Accurate 3D point cloud object detection is crucially important for autonomous driving vehicles. The sparsity of point clouds in 3D scenes, especially for smaller targets like pedestrians and bicycles that contain fewer points, makes detection particularly challenging. To solve this problem, we propose a single-stage voxel-based 3D object detection method, namely PFENet.
View Article and Find Full Text PDFA constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer.
Cancer Cell
January 2025
Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Centre for Cancer Evolution, Bart's Cancer Institute, Queen Mary University London, London EC1M 6AU, UK. Electronic address:
Fewer than 50% of metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC) patients respond to immune checkpoint inhibition (ICI). Identifying and expanding this patient population remains a pressing clinical need. Here, we report that an interferon-high immunophenotype locally enriched in cytotoxic lymphocytes and antigen-presenting macrophages is required for response.
View Article and Find Full Text PDFDevelopment of TAR-200: A novel targeted releasing system designed to provide sustained delivery of gemcitabine for patients with bladder cancer.
Urol Oncol
January 2025
Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan, Italy; Department of Medical Oncology, IRCCS San Raffaele University, Milan, Italy.
Treatment options for recurrent high-risk non-muscle-invasive bladder cancer (HR NMIBC) and muscle-invasive bladder cancer (MIBC) are limited, highlighting a need for clinically effective, accessible, and better-tolerated alternatives. In this review we examine the clinical development program of TAR-200, a novel targeted releasing system designed to provide sustained intravesical delivery of gemcitabine to address the needs of patients with NMIBC and of those with MIBC. We describe the concept and design of TAR-200 and the clinical development of this gemcitabine intravesical system in the SunRISe portfolio of studies.
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