Does cancer cell-expressed SLAMF7 impact on CD47-mediated phagocytosis?

Mol Cell Oncol

Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.

Published: April 2019

Innate immune checkpoint CD47 has emerged as a prominent target for cancer immunotherapy and defining biomarkers predictive of response will be a crucial step towards clinical implementation. Hereto, we investigated the importance of a previously reported requisite for SLAM family member 7(SLAMF7) expression on cancer cell phagocytosis for effective CD47 antibody therapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512920PMC
http://dx.doi.org/10.1080/23723556.2019.1600349DOI Listing

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