AI Article Synopsis
- The study investigates how maternal anemia affects the expression of angiogenic proteins in the placenta, focusing on VEGF, PLGF, nitrotyrosine, and e-NOS.
- In total, 48 pregnant women were analyzed, categorized into normal, mild, moderate, and severe anemia groups, with 58.3% being anemic.
- Results indicated that anemic mothers showed higher levels of these proteins in their placentas, suggesting that this may be a compensatory mechanism to adapt to altered blood flow and oxygen delivery.
Article Abstract
In this study, we hypothesized that maternal anemia leads to altered expression of angiogenic proteins vascular endothelial growth factor (VEGF), placental growth factor (PLGF), nitrotyrosine (NT) residues, and endothelial nitric oxide synthase (e-NOS) in the placenta. Hence, we study the expression of the abovementioned proteins in the placentas of mothers with different grades of anemia. Our study was conducted in 48 pregnant women (36-40 weeks of gestation), who were divided into four groups-normal, mild, moderate, and severe anemia. After delivery, the expression of the angiogenic proteins was studied in their placentas by immunohistochemistry. In our study, 58.3% of the pregnant women were anemic, among which 20.83% had mild anemia, 18.75% had moderate anemia, and 18.75% had severe anemia. Immunohistochemical staining intensity for VEGF, PLGF, NT residues, and e-NOS proteins was observed to be higher in the placentas of anemic women when compared with the non-anemic women. Our study showed that there is an increased expression of angiogenic proteins in the placentas of anemic mothers, which probably is an adaptive response leading to changes in placental vessels.
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| http://dx.doi.org/10.1080/15513815.2019.1587120 | DOI Listing |
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