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Interest of hair tests to discriminate a tail end of a doping regimen from a possible unpredictable source of a prohibited substance in case of challenging an anti-doping rule violation.
Clin Chem Lab Med
January 2025
X-Pertise Consulting, Mittelhausbergen, France.
The presence of letrozole, an aromatase inhibitor, in an athlete's sample constitutes one of the more frequent anti-doping rules violation. It is possible to challenge this violation but it is the athletes who have to demonstrate their innocence. The conditions to evidence/establish the absence of fault or negligence hinge on two points: 1.
View Article and Find Full Text PDFHigh-resolution DNA methylation changes reveal biomarkers of heart failure with preserved ejection fraction versus reduced ejection fraction.
Basic Res Cardiol
December 2024
Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
Novel biomarkers are needed to better identify-and distinguish-heart failure with preserved ejection fraction (HFpEF) from other clinical phenotypes. The goal of our study was to identify epigenetic-sensitive biomarkers useful to a more accurate diagnosis of HFpEF. We performed a network-oriented genome-wide DNA methylation study of circulating CD4 T lymphocytes isolated from peripheral blood using reduced representation bisulfite sequencing (RRBS) in two cohorts (i.
View Article and Find Full Text PDFThe Horizon of Science.
Cureus
December 2024
Physical Medicine and Rehabilitation, Foundation Don Carlo Gnocchi, Milan, ITA.
The core of science is reasoning; assessment tools are an integral part of it. Mathematical/statistical calculation is a tool and is not equivalent to clinical reasoning. Statistics establish mathematical significance but do not always equally highlight clinical relevance.
View Article and Find Full Text PDFAspirin for Secondary Prevention of Atherosclerosis-Evidence or Dogma?
JAMA Cardiol
December 2024
British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Lanarkshire, United Kingdom.
Meniscal tears affect patients of all ages, with varying presentations, influence on function, and treatment requirements. Classic dogma suggests that older patients should be treated nonoperatively or offered meniscectomy when conservative treatment fails. However, recent data suggest improved subjective outcomes and reduced rates of degenerative change after meniscal repair, even in patients older than 40 years.
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