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Color changes in the feet: a sign of autonomic symptoms in systemic sclerosis.
Rheumatology (Oxford)
September 2024
Department of Internal Medicine, The University of Texas Health Science Center at Houston, Division of Rheumatology, Houston, TX, USA.
Objectives: Patients with autonomic dysfunction, or dysautonomia, often report discoloration of their dependent extremities, which is thought to be from venous pooling or acrocyanosis. A subset of patients with systemic sclerosis (SSc) are affected by dysautonomia but may be challenging to identify. We sought to determine whether patients with SSc who report discoloration in their feet have a higher burden of autonomic symptoms, including orthostatic, gastrointestinal (GI), urinary, secretomotor, and pupillomotor.
View Article and Find Full Text PDFAcrocyanosis as a rare presentation of drug-induced cutaneous vasculitis: a case report.
BMC Rheumatol
September 2024
School of Medical Sciences, Universiti Sains Malaysia, Health Campus Kubang Kerian, Kota Bharu, Kelantan, 16150, Malaysia.
Background: Acrocyanosis is characterised by persistent bluish discolouration of the extremities, resulting from reduced peripheral blood flow leading to increased oxygen extraction. The aetiology can be divided into primary and secondary causes. While primary acrocyanosis is generally painless and has a benign course, secondary causes may lead to complications.
View Article and Find Full Text PDFRaynaud's phenomenon and positive antinuclear antibodies as first manifestation of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes): a case report.
BMC Rheumatol
May 2022
Internal Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
Background: POEMS syndrome is a rare paraneoplastic syndrome caused by plasma cell disorder almost always lambda restricted. Secondary Raynaud's phenomenon is an overlooked skin manifestation of the disease even though it is present in twenty percent of patients. On POEMS syndrome have not been described positive antinuclear antibodies (ANA) and this could lead to a misdiagnosis of autoimmune disease, mainly systemic sclerosis.
View Article and Find Full Text PDFCase Report: Combined Liver-Kidney Transplantation to Correct a Mutation in Complement Factor B in an Atypical Hemolytic Uremic Syndrome Patient.
Front Immunol
January 2022
Complement Research Group, Hospital La Paz Institute for Health Research (IdiPAZ), La Paz University Hospital, Madrid, Spain.
Pathogenic gain-of-function variants in complement Factor B were identified as causative of atypical Hemolytic Uremic syndrome (aHUS) in 2007. These mutations generate a reduction on the plasma levels of complement C3. A four-month-old boy was diagnosed with hypocomplementemic aHUS in May 2000, and he suffered seven recurrences during the following three years.
View Article and Find Full Text PDFLong-term Outcome of Chilblains Associated with SARS-CoV-2.
Acta Derm Venereol
December 2021
Department of Dermatology, CHU Rennes, 2 rue Henri le Guilloux, FR-35000 Rennes, France.
Numerous cases of chilblains have been observed in the course if the COVID-19 pandemic. The aims of this study were to provide comprehensive follow-up data for patients reporting chilblains, and to determine the risk factors for incomplete recovery. Patients referred to 5 hospitals in France between March and May 2020 for chilblains were surveyed on December 2020.
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