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Mechanisms of oncogenic cell competition-Paths of victory. | LitMetric

Mechanisms of oncogenic cell competition-Paths of victory.

Semin Cancer Biol

Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark. Electronic address:

Published: June 2020

AI Article Synopsis

Article Abstract

Cancer is a multistep process. In the early phases of this disease, mutations in oncogenes and tumor suppressors are thought to promote clonal expansion. These mutations can increase cell competitiveness, allowing tumor cells to grow within the tissue by eliminating wild type host cells. Recent studies have shown that cell competition can also function in later phases of cancer. Here, we examine the existing evidence linking cell competition and tumorigenesis. We focus on the mechanisms underlying cell competition and their contribution to disease pathogenesis.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcancer.2019.05.015DOI Listing

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